1y8j

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[[Image:1y8j.gif|left|200px]]<br /><applet load="1y8j" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1y8j.gif|left|200px]]
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caption="1y8j, resolution 2.25&Aring;" />
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'''Crystal Structure of human NEP complexed with an imidazo[4,5-c]pyridine inhibitor'''<br />
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{{Structure
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|PDB= 1y8j |SIZE=350|CAPTION= <scene name='initialview01'>1y8j</scene>, resolution 2.25&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene> and <scene name='pdbligand=STS:2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM'>STS</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Neprilysin Neprilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.11 3.4.24.11]
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|GENE= MME, EPN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''Crystal Structure of human NEP complexed with an imidazo[4,5-c]pyridine inhibitor'''
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==Disease==
==Disease==
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==About this Structure==
==About this Structure==
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1Y8J is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=ACT:'>ACT</scene> and <scene name='pdbligand=STS:'>STS</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Neprilysin Neprilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.11 3.4.24.11] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y8J OCA].
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1Y8J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y8J OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Neprilysin]]
[[Category: Neprilysin]]
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[[Category: lt1_6]]
[[Category: lt1_6]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:02:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:19:42 2008''

Revision as of 13:19, 20 March 2008

Image:1y8j.gif


PDB ID 1y8j

Drag the structure with the mouse to rotate
, resolution 2.25Å
Ligands: , , and
Gene: MME, EPN (Homo sapiens)
Activity: Neprilysin, with EC number 3.4.24.11
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of human NEP complexed with an imidazo[4,5-c]pyridine inhibitor


Disease

Known diseases associated with this structure: Membranous glomerulonephritis, antenatal OMIM:[120520], Neutral endopeptidase deficiency OMIM:[120520], Schizophrenia, susceptibility to OMIM:[607265]

About this Structure

1Y8J is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Mar 20 15:19:42 2008

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OCA

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