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3bwp

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[[Image:3bwp.png|left|200px]]
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==Crystal structure of a self-spliced group II intron==
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<StructureSection load='3bwp' size='340' side='right' caption='[[3bwp]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3bwp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BWP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BWP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bwp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bwp RCSB], [http://www.ebi.ac.uk/pdbsum/3bwp PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Group II introns are self-splicing ribozymes that catalyze their own excision from precursor transcripts and insertion into new genetic locations. Here we report the crystal structure of an intact, self-spliced group II intron from Oceanobacillus iheyensis at 3.1 angstrom resolution. An extensive network of tertiary interactions facilitates the ordered packing of intron subdomains around a ribozyme core that includes catalytic domain V. The bulge of domain V adopts an unusual helical structure that is located adjacent to a major groove triple helix (catalytic triplex). The bulge and catalytic triplex jointly coordinate two divalent metal ions in a configuration that is consistent with a two-metal ion mechanism for catalysis. Structural and functional analogies support the hypothesis that group II introns and the spliceosome share a common ancestor.
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{{STRUCTURE_3bwp| PDB=3bwp | SCENE= }}
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Crystal structure of a self-spliced group II intron.,Toor N, Keating KS, Taylor SD, Pyle AM Science. 2008 Apr 4;320(5872):77-82. PMID:18388288<ref>PMID:18388288</ref>
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===Crystal structure of a self-spliced group II intron===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_18388288}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3bwp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BWP OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:018388288</ref><references group="xtra"/>
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[[Category: Keating, K S.]]
[[Category: Keating, K S.]]
[[Category: Pyle, A M.]]
[[Category: Pyle, A M.]]

Revision as of 09:26, 5 November 2014

Crystal structure of a self-spliced group II intron

3bwp, resolution 3.10Å

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