2quq

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[[Image:2quq.png|left|200px]]
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==Crystal Structure of the Essential Inner Kinetochore Protein Cep3p==
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<StructureSection load='2quq' size='340' side='right' caption='[[2quq]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2quq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QUQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QUQ FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CBF3B, CEP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2quq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2quq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2quq RCSB], [http://www.ebi.ac.uk/pdbsum/2quq PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In budding yeast, the four-protein CBF3 complex (Skp1p-Ctf13p-Cep3p-Ndc10p) initiates kinetochore assembly by binding to the CDEIII locus of centromeric DNA. A Cep3p dimer recruits a Skp1p-Ctf13p heterodimer and contacts two sites on CDEIII. We report here the crystal structure, determined at 2.8 A resolution by multiple isomorphous replacement with anomalous scattering, of a truncated Cep3p (Cep3p [47-608]), comprising all but an N-terminal, Zn(2)Cys(6)-cluster, DNA-binding module. Cep3p has a well-ordered structure throughout essentially all of its polypeptide chain, unlike most yeast transcription factors, including those with Zn(2)Cys(6) clusters, such as Gal4p. This difference may reflect an underlying functional distinction: whereas any particular transcription factor must adapt to a variety of upstream activating sites, Cep3p scaffolds kinetochore assembly on centromeres uniformly configured on all 16 yeast chromosomes. We have, using the structure of Cep3p (47-608) and the known structures of Zn(2)Cys(6)-cluster domains, modeled the interaction of Cep3p with CDEIII.
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{{STRUCTURE_2quq| PDB=2quq | SCENE= }}
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Crystal structure of the yeast inner kinetochore subunit Cep3p.,Bellizzi JJ 3rd, Sorger PK, Harrison SC Structure. 2007 Nov;15(11):1422-30. PMID:17997968<ref>PMID:17997968</ref>
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===Crystal Structure of the Essential Inner Kinetochore Protein Cep3p===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_17997968}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2quq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QUQ OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:017997968</ref><references group="xtra"/>
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Harrison, S C.]]
[[Category: Harrison, S C.]]

Revision as of 11:34, 20 October 2014

Crystal Structure of the Essential Inner Kinetochore Protein Cep3p

2quq, resolution 2.80Å

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