2w8x

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[[Image:2w8x.png|left|200px]]
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==STRUCTURE OF THE TICK ION-CHANNEL MODULATOR RA-KLP==
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<StructureSection load='2w8x' size='340' side='right' caption='[[2w8x]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2w8x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhipicephalus_appendiculatus Rhipicephalus appendiculatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W8X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W8X FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w8x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w8x RCSB], [http://www.ebi.ac.uk/pdbsum/2w8x PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Ra-KLP, a 75 amino acid protein secreted by the salivary gland of the brown ear tick Rhipicephalus appendiculatus has a sequence resembling those of Kunitz/BPTI proteins. We report the detection, purification and characterization of the function of Ra-KLP. In addition, determination of the three-dimensional crystal structure of Ra-KLP at 1.6 A resolution using sulphur single-wavelength anomalous dispersion reveals that much of the loop structure of classical Kunitz domains, including the protruding protease-binding loop, has been replaced by beta-strands. Even more unusually, the N-terminal portion of the polypeptide chain is pinned to the "Kunitz head" by two disulphide bridges not found in classical Kunitz/BPTI proteins. The disulphide bond pattern has been further altered by the loss of the bridge that normally stabilizes the protease-binding loop. Consistent with the conversion of this loop into a beta-strand, Ra-KLP shows no significant anti-protease activity; however, it activates maxiK channels in an in vitro system, suggesting a potential mechanism for regulating host blood supply during feeding.
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{{STRUCTURE_2w8x| PDB=2w8x | SCENE= }}
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An ion-channel modulator from the saliva of the brown ear tick has a highly modified Kunitz/BPTI structure.,Paesen GC, Siebold C, Dallas ML, Peers C, Harlos K, Nuttall PA, Nunn MA, Stuart DI, Esnouf RM J Mol Biol. 2009 Jun 19;389(4):734-47. Epub 2009 Apr 24. PMID:19394347<ref>PMID:19394347</ref>
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===STRUCTURE OF THE TICK ION-CHANNEL MODULATOR RA-KLP===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_19394347}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2w8x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhipicephalus_appendiculatus Rhipicephalus appendiculatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W8X OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:019394347</ref><references group="xtra"/>
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[[Category: Rhipicephalus appendiculatus]]
[[Category: Rhipicephalus appendiculatus]]
[[Category: Dallas, M.]]
[[Category: Dallas, M.]]

Revision as of 11:24, 20 October 2014

STRUCTURE OF THE TICK ION-CHANNEL MODULATOR RA-KLP

2w8x, resolution 1.60Å

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