4b04

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'''Unreleased structure'''
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{{STRUCTURE_4b04| PDB=4b04 | SCENE= }}
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===Crystal structure of the Catalytic Domain of Human DUSP26 (C152S)===
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{{ABSTRACT_PUBMED_23695260}}
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The entry 4b04 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/DUS26_HUMAN DUS26_HUMAN]] Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).<ref>PMID:15796912</ref> <ref>PMID:16924234</ref> <ref>PMID:17001450</ref> <ref>PMID:16581800</ref>
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Authors: Won, E.Y., Lee, D.Y., Park, S.G., Yokoyama, S., Kim, S.J., Chi, S.W.
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==About this Structure==
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[[4b04]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B04 OCA].
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Description: Crystal structure of the Catalytic Domain of Human DUSP26 (C152S)
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==Reference==
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<ref group="xtra">PMID:023695260</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Chi, S W.]]
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[[Category: Kim, S J.]]
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[[Category: Lee, D Y.]]
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[[Category: Park, S G.]]
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[[Category: Won, E Y.]]
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[[Category: Yokoyama, S.]]
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[[Category: Hydrolase]]

Revision as of 13:30, 19 June 2013

Template:STRUCTURE 4b04

Contents

Crystal structure of the Catalytic Domain of Human DUSP26 (C152S)

Template:ABSTRACT PUBMED 23695260

Function

[DUS26_HUMAN] Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).[1] [2] [3] [4]

About this Structure

4b04 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Won EY, Xie Y, Takemoto C, Chen L, Liu ZJ, Wang BC, Lee D, Woo EJ, Park SG, Shirouzu M, Yokoyama S, Kim SJ, Chi SW. High-resolution crystal structure of the catalytic domain of human dual-specificity phosphatase 26. Acta Crystallogr D Biol Crystallogr. 2013 Jun;69(Pt 6):1160-70. doi:, 10.1107/S0907444913004770. Epub 2013 May 16. PMID:23695260 doi:10.1107/S0907444913004770
  1. ↑ Vasudevan SA, Skoko J, Wang K, Burlingame SM, Patel PN, Lazo JS, Nuchtern JG, Yang J. MKP-8, a novel MAPK phosphatase that inhibits p38 kinase. Biochem Biophys Res Commun. 2005 May 6;330(2):511-8. PMID:15796912 doi:10.1016/j.bbrc.2005.03.028
  2. ↑ Yu W, Imoto I, Inoue J, Onda M, Emi M, Inazawa J. A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity. Oncogene. 2007 Feb 22;26(8):1178-87. Epub 2006 Aug 21. PMID:16924234 doi:10.1038/sj.onc.1209899
  3. ↑ Takagaki K, Shima H, Tanuma N, Nomura M, Satoh T, Watanabe M, Kikuchi K. Characterization of a novel low-molecular-mass dual specificity phosphatase-4 (LDP-4) expressed in brain. Mol Cell Biochem. 2007 Feb;296(1-2):177-84. Epub 2006 Sep 26. PMID:17001450 doi:10.1007/s11010-006-9313-5
  4. ↑ Hu Y, Mivechi NF. Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26. Mol Cell Biol. 2006 Apr;26(8):3282-94. PMID:16581800 doi:26/8/3282

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