1yhp

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[[Image:1yhp.gif|left|200px]]<br /><applet load="1yhp" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1yhp.gif|left|200px]]
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caption="1yhp" />
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'''Solution Structure of Ca2+-free DdCAD-1'''<br />
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{{Structure
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|PDB= 1yhp |SIZE=350|CAPTION= <scene name='initialview01'>1yhp</scene>
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= cadA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44689 Dictyostelium discoideum])
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}}
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'''Solution Structure of Ca2+-free DdCAD-1'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1YHP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YHP OCA].
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1YHP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YHP OCA].
==Reference==
==Reference==
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Solution structures of the adhesion molecule DdCAD-1 reveal new insights into Ca(2+)-dependent cell-cell adhesion., Lin Z, Sriskanthadevan S, Huang H, Siu CH, Yang D, Nat Struct Mol Biol. 2006 Nov;13(11):1016-22. Epub 2006 Oct 22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17057715 17057715]
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Solution structures of the adhesion molecule DdCAD-1 reveal new insights into Ca(2+)-dependent cell-cell adhesion., Lin Z, Sriskanthadevan S, Huang H, Siu CH, Yang D, Nat Struct Mol Biol. 2006 Nov;13(11):1016-22. Epub 2006 Oct 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17057715 17057715]
[[Category: Dictyostelium discoideum]]
[[Category: Dictyostelium discoideum]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: nmr]]
[[Category: nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:05:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:22:59 2008''

Revision as of 13:23, 20 March 2008


PDB ID 1yhp

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Gene: cadA (Dictyostelium discoideum)
Coordinates: save as pdb, mmCIF, xml



Solution Structure of Ca2+-free DdCAD-1


Overview

DdCAD-1 is a novel Ca(2+)-dependent cell adhesion molecule that lacks a hydrophobic signal peptide and a transmembrane domain. DdCAD-1 is expressed by the social amoeba Dictyostelium discoideum at the onset of development. It is synthesized as a soluble protein and then transported to the plasma membrane by contractile vacuoles. Here we describe the novel features of the solution structures of Ca(2+)-free and Ca(2+)-bound monomeric DdCAD-1. DdCAD-1 contains two beta-sandwich domains, belonging to the betagamma-crystallin and immunoglobulin fold classes, respectively. Whereas the N-terminal domain has a major role in homophilic binding, the C-terminal domain tethers the protein to the cell membrane. From structural and mutational analyses, we propose a model for the Ca(2+)-bound DdCAD-1 dimer as a basis for understanding DdCAD-1-mediated cell-cell adhesion at the molecular level. Our results provide new insights into Ca(2+)-dependent mechanisms for cell-cell adhesion.

About this Structure

1YHP is a Single protein structure of sequence from Dictyostelium discoideum. Full crystallographic information is available from OCA.

Reference

Solution structures of the adhesion molecule DdCAD-1 reveal new insights into Ca(2+)-dependent cell-cell adhesion., Lin Z, Sriskanthadevan S, Huang H, Siu CH, Yang D, Nat Struct Mol Biol. 2006 Nov;13(11):1016-22. Epub 2006 Oct 22. PMID:17057715

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