1yia
From Proteopedia
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| - | [[Image:1yia.gif|left|200px]] | + | [[Image:1yia.gif|left|200px]] |
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| - | '''Crystal structure of tryptophanyl tRNA synthetase II from Deinococcus radiodurans in complex with 5-Hydroxy tryptophan.''' | + | {{Structure |
| + | |PDB= 1yia |SIZE=350|CAPTION= <scene name='initialview01'>1yia</scene>, resolution 3.7Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=HRP:5-HYDROXY-L-TRYPTOPHAN'>HRP</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Tryptophan--tRNA_ligase Tryptophan--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.2 6.1.1.2] | ||
| + | |GENE= DR1093 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243230 Deinococcus radiodurans R1]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of tryptophanyl tRNA synthetase II from Deinococcus radiodurans in complex with 5-Hydroxy tryptophan.''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1YIA is a [ | + | 1YIA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans_r1 Deinococcus radiodurans r1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YIA OCA]. |
==Reference== | ==Reference== | ||
| - | Structure and activity of an aminoacyl-tRNA synthetase that charges tRNA with nitro-tryptophan., Buddha MR, Crane BR, Nat Struct Mol Biol. 2005 Mar;12(3):274-5. Epub 2005 Feb 20. PMID:[http:// | + | Structure and activity of an aminoacyl-tRNA synthetase that charges tRNA with nitro-tryptophan., Buddha MR, Crane BR, Nat Struct Mol Biol. 2005 Mar;12(3):274-5. Epub 2005 Feb 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15723076 15723076] |
[[Category: Deinococcus radiodurans r1]] | [[Category: Deinococcus radiodurans r1]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: trna synthetase]] | [[Category: trna synthetase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:23:13 2008'' |
Revision as of 13:23, 20 March 2008
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| , resolution 3.7Å | |||||||
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| Ligands: | |||||||
| Gene: | DR1093 (Deinococcus radiodurans R1) | ||||||
| Activity: | Tryptophan--tRNA ligase, with EC number 6.1.1.2 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of tryptophanyl tRNA synthetase II from Deinococcus radiodurans in complex with 5-Hydroxy tryptophan.
Overview
The most divergent of two tryptophanyl tRNA synthetases (TrpRS II) found in Deinococcus radiodurans interacts with a nitric oxide synthase protein that produces 4-nitro-tryptophan (4-NRP). TrpRS II efficiently charges transfer RNA(Trp) with 4-NRP and 5-hydroxy-tryptophan (5-HRP). The crystal structures of TrpRS II bound to tryptophan and 5-HRP reveal residue substitutions that accommodate modified indoles. A class of auxiliary bacterial TrpRSs conserve this capacity to charge tRNA with nonstandard amino acids.
About this Structure
1YIA is a Single protein structure of sequence from Deinococcus radiodurans r1. Full crystallographic information is available from OCA.
Reference
Structure and activity of an aminoacyl-tRNA synthetase that charges tRNA with nitro-tryptophan., Buddha MR, Crane BR, Nat Struct Mol Biol. 2005 Mar;12(3):274-5. Epub 2005 Feb 20. PMID:15723076
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