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3ejg

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[[Image:3ejg.png|left|200px]]
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==Crystal structure of HCoV-229E X-domain==
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<StructureSection load='3ejg' size='340' side='right' caption='[[3ejg]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ejg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_coronavirus_229e Human coronavirus 229e]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EJG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EJG FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ejf|3ejf]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">1a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11137 Human coronavirus 229E])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ejg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ejg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ejg RCSB], [http://www.ebi.ac.uk/pdbsum/3ejg PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ej/3ejg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The polyproteins of coronaviruses are cleaved by viral proteases into at least 15 nonstructural proteins (Nsps). Consisting of five domains, Nsp3 is the largest of these (180-210 kDa). Among these domains, the so-called X-domain is believed to act as ADP-ribose-1''-phosphate phosphatase or to bind poly(ADP-ribose). However, here we show that the X-domain of Infectious Bronchitis Virus (strain Beaudette), a Group-3 coronavirus, fails to bind ADP-ribose. This is explained on the basis of the crystal structure of the protein, determined at two different pH values. For comparison, we also describe the crystal structure of the homologous X-domain from Human Coronavirus 229E, a Group-1 coronavirus, which does bind ADP-ribose.
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{{STRUCTURE_3ejg| PDB=3ejg | SCENE= }}
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Crystal structures of the X-domains of a Group-1 and a Group-3 coronavirus reveal that ADP-ribose-binding may not be a conserved property.,Piotrowski Y, Hansen G, Boomaars-van der Zanden AL, Snijder EJ, Gorbalenya AE, Hilgenfeld R Protein Sci. 2009 Jan;18(1):6-16. PMID:19177346<ref>PMID:19177346</ref>
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===Crystal structure of HCoV-229E X-domain===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_19177346}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3ejg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_coronavirus_229e Human coronavirus 229e]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EJG OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:019177346</ref><references group="xtra"/>
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[[Category: Human coronavirus 229e]]
[[Category: Human coronavirus 229e]]
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[[Category: Hansen, G.]]
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[[Category: Hansen, G]]
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[[Category: Hilgenfeld, R.]]
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[[Category: Hilgenfeld, R]]
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[[Category: Piotrowski, Y.]]
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[[Category: Piotrowski, Y]]
[[Category: Adrp]]
[[Category: Adrp]]
[[Category: Hcov 229e]]
[[Category: Hcov 229e]]

Revision as of 13:21, 19 November 2014

Crystal structure of HCoV-229E X-domain

3ejg, resolution 1.78Å

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