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3e9s

From Proteopedia

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m (Protected "3e9s" [edit=sysop:move=sysop])
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[[Image:3e9s.png|left|200px]]
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==A new class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication==
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<StructureSection load='3e9s' size='340' side='right' caption='[[3e9s]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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{{STRUCTURE_3e9s| PDB=3e9s | SCENE= }}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3e9s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E9S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3E9S FirstGlance]. <br>
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===A new class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication===
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TTT:5-AMINO-2-METHYL-N-[(1R)-1-NAPHTHALEN-1-YLETHYL]BENZAMIDE'>TTT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
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{{ABSTRACT_PUBMED_018852458}}
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2fe8|2fe8]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">1a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=227859 SARS coronavirus])</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e9s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3e9s RCSB], [http://www.ebi.ac.uk/pdbsum/3e9s PDBsum]</span></td></tr>
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[[3e9s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E9S OCA].
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e9/3e9s_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Sars coronavirus]]
[[Category: Sars coronavirus]]
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[[Category: Mesecar, A D.]]
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[[Category: Mesecar, A D]]
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[[Category: Pegan, S.]]
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[[Category: Pegan, S]]
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[[Category: Ratia, K.]]
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[[Category: Ratia, K]]
[[Category: Coronavirus]]
[[Category: Coronavirus]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]

Revision as of 13:32, 19 November 2014

A new class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication

3e9s, resolution 2.50Å

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OCA

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