3efy

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[[Image:3efy.png|left|200px]]
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==Structure of the Cyclomodulin Cif from Pathogenic Escherichia coli==
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<StructureSection load='3efy' size='340' side='right' caption='[[3efy]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3efy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EFY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EFY FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cif ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3efy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3efy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3efy RCSB], [http://www.ebi.ac.uk/pdbsum/3efy PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Bacterial pathogens have evolved a sophisticated arsenal of virulence factors to modulate host cell biology. Enteropathogenic and enterohemorrhagic Escherichia coli (EPEC and EHEC) use a type III protein secretion system (T3SS) to inject microbial proteins into host cells. The T3SS effector cycle inhibiting factor (Cif) produced by EPEC and EHEC is able to block host eukaryotic cell-cycle progression. We present here a crystal structure of Cif, revealing it to be a divergent member of the superfamily of enzymes including cysteine proteases and acetyltransferases that share a common catalytic triad. Mutation of these conserved active site residues abolishes the ability of Cif to block cell-cycle progression. Finally, we demonstrate that irreversible cysteine protease inhibitors do not abolish the Cif cytopathic effect, suggesting that another enzymatic activity may underlie the biological activity of this virulence factor.
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{{STRUCTURE_3efy| PDB=3efy | SCENE= }}
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Structure of the cyclomodulin Cif from pathogenic Escherichia coli.,Hsu Y, Jubelin G, Taieb F, Nougayrede JP, Oswald E, Stebbins CE J Mol Biol. 2008 Dec 12;384(2):465-77. Epub 2008 Sep 27. PMID:18845161<ref>PMID:18845161</ref>
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===Structure of the Cyclomodulin Cif from Pathogenic Escherichia coli===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_18845161}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3efy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EFY OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:018845161</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Hsu, Y.]]
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[[Category: Hsu, Y]]
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[[Category: Stebbins, C E.]]
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[[Category: Stebbins, C E]]
[[Category: Bacteria]]
[[Category: Bacteria]]
[[Category: Cell cycle]]
[[Category: Cell cycle]]

Revision as of 13:37, 19 November 2014

Structure of the Cyclomodulin Cif from Pathogenic Escherichia coli

3efy, resolution 1.70Å

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