4iej

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[[Image:4iej.png|left|200px]]
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==Crystal structure of a DNA methyltransferase 1 associated protein 1 (DMAP1) from Homo sapiens at 1.45 A resolution==
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<StructureSection load='4iej' size='340' side='right' caption='[[4iej]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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{{STRUCTURE_4iej| PDB=4iej | SCENE= }}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4iej]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IEJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IEJ FirstGlance]. <br>
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===Crystal structure of a DNA methyltransferase 1 associated protein 1 (DMAP1) from Homo sapiens at 1.45 A resolution===
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BC008053, DMAP1, KIAA1425 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iej OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iej RCSB], [http://www.ebi.ac.uk/pdbsum/4iej PDBsum]</span></td></tr>
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==About this Structure==
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</table>
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[[4iej]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IEJ OCA].
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== Function ==
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[[http://www.uniprot.org/uniprot/DMAP1_HUMAN DMAP1_HUMAN]] Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity.<ref>PMID:14665632</ref> <ref>PMID:14978102</ref> <ref>PMID:14966270</ref> <ref>PMID:15367675</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: JCSG, Joint Center for Structural Genomics.]]
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[[Category: Structural genomic]]
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[[Category: TCELL, Partnership for T-Cell Biology.]]
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[[Category: TCELL, Partnership for T-Cell Biology]]
[[Category: Chromatin regulator]]
[[Category: Chromatin regulator]]
[[Category: Dna methylation]]
[[Category: Dna methylation]]
[[Category: Jcsg]]
[[Category: Jcsg]]
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[[Category: Joint center for structural genomic]]
 
[[Category: Partnership for t-cell biology]]
[[Category: Partnership for t-cell biology]]
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[[Category: Protein structure initiative]]
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[[Category: PSI, Protein structure initiative]]
[[Category: Psi-biology]]
[[Category: Psi-biology]]
[[Category: Repressor]]
[[Category: Repressor]]
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[[Category: Structural genomic]]
 
[[Category: Tcell]]
[[Category: Tcell]]
[[Category: Transcription]]
[[Category: Transcription]]

Revision as of 21:18, 24 December 2014

Crystal structure of a DNA methyltransferase 1 associated protein 1 (DMAP1) from Homo sapiens at 1.45 A resolution

4iej, resolution 1.45Å

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