1yrk

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[[Image:1yrk.gif|left|200px]]<br /><applet load="1yrk" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1yrk.gif|left|200px]]
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caption="1yrk, resolution 1.70&Aring;" />
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'''The C2 Domain of PKC<delta> is a new Phospho-Tyrosine Binding Domain'''<br />
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{{Structure
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|PDB= 1yrk |SIZE=350|CAPTION= <scene name='initialview01'>1yrk</scene>, resolution 1.70&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=ACY:ACETIC ACID'>ACY</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''The C2 Domain of PKC<delta> is a new Phospho-Tyrosine Binding Domain'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1YRK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ACY:'>ACY</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YRK OCA].
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1YRK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YRK OCA].
==Reference==
==Reference==
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C2 can do it, too., Sondermann H, Kuriyan J, Cell. 2005 Apr 22;121(2):158-60. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15851022 15851022]
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C2 can do it, too., Sondermann H, Kuriyan J, Cell. 2005 Apr 22;121(2):158-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15851022 15851022]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: c2 domain]]
[[Category: c2 domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:08:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:26:34 2008''

Revision as of 13:26, 20 March 2008

Image:1yrk.gif


PDB ID 1yrk

Drag the structure with the mouse to rotate
, resolution 1.70Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



The C2 Domain of PKC<delta> is a new Phospho-Tyrosine Binding Domain


Overview

In this issue of Cell, report that the C2 domain of the serine/threonine protein kinase Cdelta is a phosphotyrosine binding domain and present the crystal structure of this C2 domain bound to a peptide containing phosphotyrosine. Prior to this work, C2 domains were thought to bind only to phospholipids or to unphosphorylated proteins, and the SH2 and PTB domains were the only signaling domains known to recognize phosphotyrosine. This new role for the C2 domain links phosphotyrosine recognition directly to serine/threonine kinase activity and reveals an unexpected mechanism for crosstalk between distinct signaling pathways.

About this Structure

1YRK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

C2 can do it, too., Sondermann H, Kuriyan J, Cell. 2005 Apr 22;121(2):158-60. PMID:15851022

Page seeded by OCA on Thu Mar 20 15:26:34 2008

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