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1ysv

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[[Image:1ysv.gif|left|200px]]<br /><applet load="1ysv" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1ysv.gif|left|200px]]
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caption="1ysv" />
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'''Solution structure of the central region of the human GluR-B R/G pre-mRNA'''<br />
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{{Structure
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|PDB= 1ysv |SIZE=350|CAPTION= <scene name='initialview01'>1ysv</scene>
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''Solution structure of the central region of the human GluR-B R/G pre-mRNA'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1YSV is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSV OCA].
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1YSV is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSV OCA].
==Reference==
==Reference==
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A novel RNA pentaloop fold involved in targeting ADAR2., Stefl R, Allain FH, RNA. 2005 May;11(5):592-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15840813 15840813]
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A novel RNA pentaloop fold involved in targeting ADAR2., Stefl R, Allain FH, RNA. 2005 May;11(5):592-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15840813 15840813]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Allain, F H.]]
[[Category: Allain, F H.]]
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[[Category: structure]]
[[Category: structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:08:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:27:02 2008''

Revision as of 13:27, 20 March 2008

Image:1ysv.gif


PDB ID 1ysv

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Coordinates: save as pdb, mmCIF, xml



Solution structure of the central region of the human GluR-B R/G pre-mRNA


Overview

Adenosine deaminases that act on RNA (ADARs) catalyze the site-specific conversion of adenosine to inosine in primary mRNA transcripts, thereby affecting coding potential of mature mRNAs. Structural determinants that define the adenosine moieties for specific ADARs-mediated deaminations are currently unknown. We report the solution structure of the central region of the human R/G stem-loop pre-mRNA, a natural ADAR2 substrate encoding the subunit B of the glutamate receptor (R/G site). The structure reveals that the GCU(A/C)A pentaloop that is conserved in mammals and birds adopts a novel fold. The fold is stabilized by a complex interplay of hydrogen bonds and stacking interactions. We propose that this new pentaloop structure is an important determinant of the R/G site recognition by ADAR2.

About this Structure

1YSV is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

A novel RNA pentaloop fold involved in targeting ADAR2., Stefl R, Allain FH, RNA. 2005 May;11(5):592-7. PMID:15840813

Page seeded by OCA on Thu Mar 20 15:27:02 2008

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