1yty
From Proteopedia
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| - | [[Image:1yty.gif|left|200px]] | + | [[Image:1yty.gif|left|200px]] |
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| - | '''Structural basis for recognition of UUUOH 3'-terminii of nascent RNA pol III transcripts by La autoantigen''' | + | {{Structure |
| + | |PDB= 1yty |SIZE=350|CAPTION= <scene name='initialview01'>1yty</scene>, resolution 2.29Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= SSB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''Structural basis for recognition of UUUOH 3'-terminii of nascent RNA pol III transcripts by La autoantigen''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1YTY is a [ | + | 1YTY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YTY OCA]. |
==Reference== | ==Reference== | ||
| - | Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen., Teplova M, Yuan YR, Phan AT, Malinina L, Ilin S, Teplov A, Patel DJ, Mol Cell. 2006 Jan 6;21(1):75-85. PMID:[http:// | + | Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen., Teplova M, Yuan YR, Phan AT, Malinina L, Ilin S, Teplov A, Patel DJ, Mol Cell. 2006 Jan 6;21(1):75-85. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16387655 16387655] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: protein-rna complex]] | [[Category: protein-rna complex]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:27:26 2008'' |
Revision as of 13:27, 20 March 2008
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| , resolution 2.29Å | |||||||
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| Gene: | SSB (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structural basis for recognition of UUUOH 3'-terminii of nascent RNA pol III transcripts by La autoantigen
Overview
The nuclear phosphoprotein La was identified as an autoantigen in patients with systemic lupus erythematosus and Sjogren's syndrome. La binds to and protects the UUU(OH) 3' terminii of nascent RNA polymerase III transcripts from exonuclease digestion. We report the 1.85 angstroms crystal structure of the N-terminal domain of human La, consisting of La and RRM1 motifs, bound to r(U1-G2-C3-U4-G5-U6-U7-U8-U9OH). The U7-U8-U9OH 3' end, in a splayed-apart orientation, is sequestered within a basic and aromatic amino acid-lined cleft between the La and RRM1 motifs. The specificity-determining U8 residue bridges both motifs, in part through unprecedented targeting of the beta sheet edge, rather than the anticipated face, of the RRM1 motif. Our structural observations, supported by mutation studies of both La and RNA components, illustrate the principles behind RNA sequestration by a rheumatic disease autoantigen, whereby the UUU(OH) 3' ends of nascent RNA transcripts are protected during downstream processing and maturation events.
About this Structure
1YTY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen., Teplova M, Yuan YR, Phan AT, Malinina L, Ilin S, Teplov A, Patel DJ, Mol Cell. 2006 Jan 6;21(1):75-85. PMID:16387655
Page seeded by OCA on Thu Mar 20 15:27:26 2008
