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1h8a

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[[Image:1h8a.png|left|200px]]
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==CRYSTAL STRUCTURE OF TERNARY PROTEIN-DNA COMPLEX3==
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<StructureSection load='1h8a' size='340' side='right' caption='[[1h8a]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1h8a]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Avian_myeloblastosis_virus Avian myeloblastosis virus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H8A FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1h88|1h88]], [[1h89|1h89]], [[1hjb|1hjb]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h8a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h8a RCSB], [http://www.ebi.ac.uk/pdbsum/1h8a PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h8/1h8a_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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c-Myb, but not avian myeloblastosis virus (AMV) v-Myb, cooperates with C/EBP beta to regulate transcription of myeloid-specific genes. To assess the structural basis for that difference, we determined the crystal structures of complexes comprised of the c-Myb or AMV v-Myb DNA-binding domain (DBD), the C/EBP beta DBD, and a promoter DNA fragment. Within the c-Myb complex, a DNA-bound C/EBP beta interacts with R2 of c-Myb bound to a different DNA fragment; point mutations in v-Myb R2 eliminate such interaction within the v-Myb complex. GST pull-down assays, luciferase trans-activation assays, and atomic force microscopy confirmed that the interaction of c-Myb and C/EBP beta observed in crystal mimics their long range interaction on the promoter, which is accompanied by intervening DNA looping.
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{{STRUCTURE_1h8a| PDB=1h8a | SCENE= }}
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Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter.,Tahirov TH, Sato K, Ichikawa-Iwata E, Sasaki M, Inoue-Bungo T, Shiina M, Kimura K, Takata S, Fujikawa A, Morii H, Kumasaka T, Yamamoto M, Ishii S, Ogata K Cell. 2002 Jan 11;108(1):57-70. PMID:11792321<ref>PMID:11792321</ref>
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===CRYSTAL STRUCTURE OF TERNARY PROTEIN-DNA COMPLEX3===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_11792321}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1h8a]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Avian_myeloblastosis_virus Avian myeloblastosis virus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8A OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:011792321</ref><references group="xtra"/>
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[[Category: Avian myeloblastosis virus]]
[[Category: Avian myeloblastosis virus]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]

Revision as of 14:39, 29 September 2014

CRYSTAL STRUCTURE OF TERNARY PROTEIN-DNA COMPLEX3

1h8a, resolution 2.23Å

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