1oz8

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[[Image:1oz8.png|left|200px]]
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==Intramolecular higher-order packing of parallel quadruplexes comprising a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad of GGA triplet repeat DNA==
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<StructureSection load='1oz8' size='340' side='right' caption='[[1oz8]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1oz8]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OZ8 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oz8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oz8 RCSB], [http://www.ebi.ac.uk/pdbsum/1oz8 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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GGA triplet repeats are widely dispersed throughout eukaryotic genomes and are frequently located within biologically important regions such as gene regulatory regions and recombination hot spot sites. We determined the structure of d(GGA)4 (12-mer) under physiological conditions and founded the formation of an intramolecular parallel quadruplex for the first time. Later, a similar architecture to that of the intramolecular parallel quadruplex was found for a telomere DNA in the crystalline state. Here, we have determined the structure of d(GGA)8 (24-mer) under physiological conditions. Two intramolecular parallel quadruplexes comprising a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad are formed in d(GGA)8. These quadruplexes are packed in a tail-to-tail manner. This is the first demonstration of the intramolecular higher order packing of quadruplexes at atomic resolution. K+ ions, but not Na+ ones, are critically required for the formation of this unique structure. The elucidated structure suggests the mechanisms underlying the biological events related to the GGA triplet repeat. Furthermore, in the light of the structure, the mode of the higher order packing of the telomere DNA is discussed.
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{{STRUCTURE_1oz8| PDB=1oz8 | SCENE= }}
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Intramolecular higher order packing of parallel quadruplexes comprising a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad of GGA triplet repeat DNA.,Matsugami A, Okuizumi T, Uesugi S, Katahira M J Biol Chem. 2003 Jul 25;278(30):28147-53. Epub 2003 May 14. PMID:12748183<ref>PMID:12748183</ref>
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===Intramolecular higher-order packing of parallel quadruplexes comprising a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad of GGA triplet repeat DNA===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_12748183}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1oz8]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZ8 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:012748183</ref><ref group="xtra">PMID:011800555</ref><ref group="xtra">PMID:012367521</ref><references group="xtra"/>
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[[Category: Katahira, M.]]
[[Category: Katahira, M.]]
[[Category: Matsugami, A.]]
[[Category: Matsugami, A.]]

Revision as of 11:24, 20 October 2014

Intramolecular higher-order packing of parallel quadruplexes comprising a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad of GGA triplet repeat DNA

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