4hmn

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'''Unreleased structure'''
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{{STRUCTURE_4hmn| PDB=4hmn | SCENE= }}
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===Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with (4-(4-Chlorophenyl)piperazin-1-yl)(morpholino)methanone (24)===
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The entry 4hmn is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN]] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
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Authors: Turnbull, A.P., Flanagan, J.U., Atwell, G.J., Heinrich, D.M., Jamieson, S.M.F., Brooke, D.G., Silva, S., Rigoreau, L.J.M., Trivier, E., Soudy, C., Samlal, S.S., Owen, P.J., Schroeder, E., Raynham, T., Denny, W.A.
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==About this Structure==
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[[4hmn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HMN OCA].
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Description: Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with (4-(4-Chlorophenyl)piperazin-1-yl)(morpholino)methanone (24)
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[[Category: Atwell, G J.]]
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[[Category: Brooke, D G.]]
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[[Category: Denny, W A.]]
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[[Category: Flanagan, J U.]]
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[[Category: Heinrich, D M.]]
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[[Category: Jamieson, S M.F.]]
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[[Category: Owen, P J.]]
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[[Category: Raynham, T.]]
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[[Category: Rigoreau, L J.M.]]
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[[Category: Samlal, S S.]]
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[[Category: Schroeder, E.]]
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[[Category: Silva, S.]]
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[[Category: Soudy, C.]]
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[[Category: Trivier, E.]]
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[[Category: Turnbull, A P.]]
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[[Category: Aldo-keto reductase]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Tim-barrel]]

Revision as of 08:26, 13 November 2013

Template:STRUCTURE 4hmn

Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with (4-(4-Chlorophenyl)piperazin-1-yl)(morpholino)methanone (24)

Function

[AK1C3_HUMAN] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.

About this Structure

4hmn is a 1 chain structure. Full crystallographic information is available from OCA.

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OCA

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