4ibr

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'''Unreleased structure'''
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{{STRUCTURE_4ibr| PDB=4ibr | SCENE= }}
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===Crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying G238S/E104K mutations===
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The entry 4ibr is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/BLAT_ECOLX BLAT_ECOLX]] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.
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Authors: Dellus-Gur, E., Toth-Petroczy, A., Elias, M., Tawfik, D.S.
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==About this Structure==
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[[4ibr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IBR OCA].
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Description: Crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying G238S/E104K mutations
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[[Category: Beta-lactamase]]
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[[Category: Escherichia coli]]
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[[Category: Dellus-Gur, E.]]
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[[Category: Elias, M.]]
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[[Category: Tawfik, D S.]]
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[[Category: Toth-Petroczy, A.]]
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[[Category: Beta-lactamase]]
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[[Category: Hydrolase]]

Revision as of 01:49, 4 April 2013

Template:STRUCTURE 4ibr

Crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying G238S/E104K mutations

Function

[BLAT_ECOLX] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.

About this Structure

4ibr is a 1 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.

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OCA

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