4ibx

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4ibx| PDB=4ibx | SCENE= }}
 +
===Crystal structure of stabilized TEM-1 beta-lactamase variant v.13===
-
The entry 4ibx is ON HOLD until Paper Publication
+
==Function==
 +
[[http://www.uniprot.org/uniprot/BLAT_ECOLX BLAT_ECOLX]] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.
-
Authors: Dellus-Gur, E., Toth-Petroczy, A., Elias, M., Tawfik, D.S.
+
==About this Structure==
-
 
+
[[4ibx]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IBX OCA].
-
Description: Crystal structure of stabilized TEM-1 beta-lactamase variant v.13
+
[[Category: Beta-lactamase]]
 +
[[Category: Escherichia coli]]
 +
[[Category: Dellus-Gur, E.]]
 +
[[Category: Elias, M.]]
 +
[[Category: Tawfik, D S.]]
 +
[[Category: Toth-Petroczy, A.]]
 +
[[Category: Hydrolase]]
 +
[[Category: Tem-1 beta-lactamase]]

Revision as of 01:49, 4 April 2013

Template:STRUCTURE 4ibx

Crystal structure of stabilized TEM-1 beta-lactamase variant v.13

Function

[BLAT_ECOLX] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.

About this Structure

4ibx is a 5 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4ibx"
Personal tools