4g2v

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[[Image:4g2v.jpg|left|200px]]
 
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{{STRUCTURE_4g2v| PDB=4g2v | SCENE= }}
{{STRUCTURE_4g2v| PDB=4g2v | SCENE= }}
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===Structure complex of LGN binding with FRMPD1===
===Structure complex of LGN binding with FRMPD1===
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{{ABSTRACT_PUBMED_23318951}}
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==Function==
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[[http://www.uniprot.org/uniprot/GPSM2_MOUSE GPSM2_MOUSE]] Plays an important role in spindle pole orientation (By similarity). Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions. [[http://www.uniprot.org/uniprot/FRPD1_HUMAN FRPD1_HUMAN]] Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1.<ref>PMID:18566450</ref>
==About this Structure==
==About this Structure==
[[4g2v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2V OCA].
[[4g2v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2V OCA].
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==Reference==
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<ref group="xtra">PMID:023318951</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]

Revision as of 04:33, 18 July 2013

Template:STRUCTURE 4g2v

Contents

Structure complex of LGN binding with FRMPD1

Template:ABSTRACT PUBMED 23318951

Function

[GPSM2_MOUSE] Plays an important role in spindle pole orientation (By similarity). Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions. [FRPD1_HUMAN] Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1.[1]

About this Structure

4g2v is a 2 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Pan Z, Shang Y, Jia M, Zhang L, Xia C, Zhang M, Wang W, Wen W. Structural and biochemical characterization of the interaction between LGN and Frmpd1. J Mol Biol. 2013 Mar 25;425(6):1039-49. doi: 10.1016/j.jmb.2013.01.003. Epub 2013, Jan 11. PMID:23318951 doi:10.1016/j.jmb.2013.01.003
  1. ↑ An N, Blumer JB, Bernard ML, Lanier SM. The PDZ and band 4.1 containing protein Frmpd1 regulates the subcellular location of activator of G-protein signaling 3 and its interaction with G-proteins. J Biol Chem. 2008 Sep 5;283(36):24718-28. Epub 2008 Jun 19. PMID:18566450 doi:M803497200

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