1z4u

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[[Image:1z4u.gif|left|200px]]<br /><applet load="1z4u" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1z4u.gif|left|200px]]
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caption="1z4u, resolution 2.80&Aring;" />
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'''hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00799585'''<br />
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{{Structure
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|PDB= 1z4u |SIZE=350|CAPTION= <scene name='initialview01'>1z4u</scene>, resolution 2.80&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=PH9:(2Z)-2-[(1-ADAMANTYLCARBONYL)AMINO]-3-[4-(2-BROMOPHENOXY)PHENYL]PROP-2-ENOIC+ACID'>PH9</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48]
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|GENE=
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}}
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'''hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00799585'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1Z4U is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus] with <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=PH9:'>PH9</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4U OCA].
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1Z4U is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4U OCA].
==Reference==
==Reference==
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Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid., Pfefferkorn JA, Nugent R, Gross RJ, Greene M, Mitchell MA, Reding MT, Funk LA, Anderson R, Wells PA, Shelly JA, Anstadt R, Finzel BC, Harris MS, Kilkuskie RE, Kopta LA, Schwende FJ, Bioorg Med Chem Lett. 2005 Jun 2;15(11):2812-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15911260 15911260]
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Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid., Pfefferkorn JA, Nugent R, Gross RJ, Greene M, Mitchell MA, Reding MT, Funk LA, Anderson R, Wells PA, Shelly JA, Anstadt R, Finzel BC, Harris MS, Kilkuskie RE, Kopta LA, Schwende FJ, Bioorg Med Chem Lett. 2005 Jun 2;15(11):2812-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15911260 15911260]
[[Category: Hepatitis c virus]]
[[Category: Hepatitis c virus]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: PH9]]
[[Category: PH9]]
[[Category: PO4]]
[[Category: PO4]]
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[[Category: fingers]]
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[[Category: finger]]
[[Category: hcv]]
[[Category: hcv]]
[[Category: ns5b]]
[[Category: ns5b]]
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[[Category: thumb]]
[[Category: thumb]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:12:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:31:12 2008''

Revision as of 13:31, 20 March 2008

Image:1z4u.gif


PDB ID 1z4u

Drag the structure with the mouse to rotate
, resolution 2.80Å
Ligands: , , and
Activity: RNA-directed RNA polymerase, with EC number 2.7.7.48
Coordinates: save as pdb, mmCIF, xml



hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00799585


Overview

A novel series of non-nucleoside HCV NS5B polymerase inhibitors was prepared from a (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid template. Solution and solid phase analog synthesis focused on the northern region of the template combined with structure based design led to the discovery of several potent and orally bioavailable lead compounds.

About this Structure

1Z4U is a Protein complex structure of sequences from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid., Pfefferkorn JA, Nugent R, Gross RJ, Greene M, Mitchell MA, Reding MT, Funk LA, Anderson R, Wells PA, Shelly JA, Anstadt R, Finzel BC, Harris MS, Kilkuskie RE, Kopta LA, Schwende FJ, Bioorg Med Chem Lett. 2005 Jun 2;15(11):2812-8. PMID:15911260

Page seeded by OCA on Thu Mar 20 15:31:12 2008

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