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1z5l

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[[Image:1z5l.gif|left|200px]]<br /><applet load="1z5l" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1z5l.gif|left|200px]]
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caption="1z5l, resolution 2.20&Aring;" />
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'''Structure of a highly potent short-chain galactosyl ceramide agonist bound to CD1D'''<br />
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{{Structure
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|PDB= 1z5l |SIZE=350|CAPTION= <scene name='initialview01'>1z5l</scene>, resolution 2.20&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PBS:(2S,3S,4R)-N-OCTANOYL-1-[(ALPHA-D-GALACTOPYRANOSYL)OXY]-2-AMINO-OCTADECANE-3,4-DIOL'>PBS</scene> and <scene name='pdbligand=R16:HEXADECANE'>R16</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Structure of a highly potent short-chain galactosyl ceramide agonist bound to CD1D'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1Z5L is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=PBS:'>PBS</scene> and <scene name='pdbligand=R16:'>R16</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z5L OCA].
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1Z5L is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z5L OCA].
==Reference==
==Reference==
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Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor., Zajonc DM, Cantu C 3rd, Mattner J, Zhou D, Savage PB, Bendelac A, Wilson IA, Teyton L, Nat Immunol. 2005 Aug;6(8):810-8. Epub 2005 Jul 10. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16007091 16007091]
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Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor., Zajonc DM, Cantu C 3rd, Mattner J, Zhou D, Savage PB, Bendelac A, Wilson IA, Teyton L, Nat Immunol. 2005 Aug;6(8):810-8. Epub 2005 Jul 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16007091 16007091]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: mhc fold]]
[[Category: mhc fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:12:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:31:26 2008''

Revision as of 13:31, 20 March 2008

Image:1z5l.gif


PDB ID 1z5l

Drag the structure with the mouse to rotate
, resolution 2.20Å
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



Structure of a highly potent short-chain galactosyl ceramide agonist bound to CD1D


Overview

Natural killer T cells express a conserved, semi-invariant alphabeta T cell receptor that has specificity for self glycosphingolipids and microbial cell wall alpha-glycuronosylceramide antigens presented by CD1d molecules. Here we report the crystal structure of CD1d in complex with a short-chain synthetic variant of alpha-galactosylceramide at a resolution of 2.2 A. This structure elucidates the basis for the high specificity of these microbial ligands and explains the restriction of the alpha-linkage as a unique pathogen-specific pattern-recognition motif. Comparison of the binding of altered lipid ligands to CD1d and T cell receptors suggested that the differential T helper type 1-like and T helper type 2-like properties of natural killer T cells may originate largely from differences in their 'loading' in different cell types and hence in their tissue distribution in vivo.

About this Structure

1Z5L is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor., Zajonc DM, Cantu C 3rd, Mattner J, Zhou D, Savage PB, Bendelac A, Wilson IA, Teyton L, Nat Immunol. 2005 Aug;6(8):810-8. Epub 2005 Jul 10. PMID:16007091

Page seeded by OCA on Thu Mar 20 15:31:26 2008

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