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1z92
From Proteopedia
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| - | [[Image:1z92.gif|left|200px]] | + | [[Image:1z92.gif|left|200px]] |
| - | + | ||
| - | '''structure of interleukin-2 with its alpha receptor''' | + | {{Structure |
| + | |PDB= 1z92 |SIZE=350|CAPTION= <scene name='initialview01'>1z92</scene>, resolution 2.8Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= IL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), IL2RA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''structure of interleukin-2 with its alpha receptor''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1Z92 is a [ | + | 1Z92 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z92 OCA]. |
==Reference== | ==Reference== | ||
| - | The structure of interleukin-2 complexed with its alpha receptor., Rickert M, Wang X, Boulanger MJ, Goriatcheva N, Garcia KC, Science. 2005 Jun 3;308(5727):1477-80. PMID:[http:// | + | The structure of interleukin-2 complexed with its alpha receptor., Rickert M, Wang X, Boulanger MJ, Goriatcheva N, Garcia KC, Science. 2005 Jun 3;308(5727):1477-80. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15933202 15933202] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: interleukin-2 alpha receptor]] | [[Category: interleukin-2 alpha receptor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:32:37 2008'' |
Revision as of 13:32, 20 March 2008
| |||||||
| , resolution 2.8Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | IL2 (Homo sapiens), IL2RA (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
structure of interleukin-2 with its alpha receptor
Contents |
Overview
Interleukin-2 (IL-2) is an immunoregulatory cytokine that binds sequentially to the alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gammac) receptor subunits. Here we present the 2.8 angstrom crystal structure of a complex between human IL-2 and IL-2Ralpha, which interact in a docking mode distinct from that of other cytokine receptor complexes. IL-2Ralpha is composed of strand-swapped "sushi-like" domains, unlike the classical cytokine receptor fold. As a result of this domain swap, IL-2Ralpha uses a composite surface to dock into a groove on IL-2 that also serves as a binding site for antagonist drugs. With this complex, we now have representative structures for each class of hematopoietic cytokine receptor-docking modules.
Disease
Known diseases associated with this structure: Diabetes mellitus, insulin-dependent, susceptibility to, 10 OMIM:[147730], Interleukin-2 receptor, alpha chain, deficiency of OMIM:[147730], Severe combined immunodeficiency due to IL2 deficiency OMIM:[147680]
About this Structure
1Z92 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The structure of interleukin-2 complexed with its alpha receptor., Rickert M, Wang X, Boulanger MJ, Goriatcheva N, Garcia KC, Science. 2005 Jun 3;308(5727):1477-80. PMID:15933202
Page seeded by OCA on Thu Mar 20 15:32:37 2008
