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3w3n

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_3w3n| PDB=3w3n | SCENE= }}
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===Crystal structure of human TLR8 in complex with Resiquimod (R848) crystal form 3===
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{{ABSTRACT_PUBMED_23520111}}
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The entry 3w3n is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/TLR8_HUMAN TLR8_HUMAN]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:17932028</ref>
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Authors: Tanji, H., Ohto, U., Shimizu, T.
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==About this Structure==
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[[3w3n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W3N OCA].
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Description: Crystal structure of human TLR8 in complex with Resiquimod (R848) crystal form 3
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Ohto, U.]]
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[[Category: Shimizu, T.]]
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[[Category: Tanji, H.]]
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[[Category: Antivirus and antitumor drug]]
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[[Category: Antivirus and antitumor drug binding]]
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[[Category: Glycosylation]]
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[[Category: Immune system]]
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[[Category: Innate immunity]]
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[[Category: Leucine rich repeat]]
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[[Category: Receptor]]
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[[Category: Resiquimod]]
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[[Category: Rna]]
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[[Category: Rna binding]]
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[[Category: Rna receptor]]
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[[Category: Rna recognition]]
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[[Category: Secreted]]
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[[Category: Ssrna]]

Revision as of 01:31, 4 April 2013

Template:STRUCTURE 3w3n

Contents

Crystal structure of human TLR8 in complex with Resiquimod (R848) crystal form 3

Template:ABSTRACT PUBMED 23520111

Function

[TLR8_HUMAN] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.[1]

About this Structure

3w3n is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Doyle SL, Jefferies CA, Feighery C, O'Neill LA. Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase. J Biol Chem. 2007 Dec 21;282(51):36953-60. Epub 2007 Oct 11. PMID:17932028 doi:10.1074/jbc.M707682200

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OCA

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