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4b0j
From Proteopedia
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{{STRUCTURE_4b0j| PDB=4b0j | SCENE= }} | {{STRUCTURE_4b0j| PDB=4b0j | SCENE= }} | ||
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===Crystal Structure of 3-hydroxydecanoyl-Acyl Carrier Protein Dehydratase (FabA) from Pseudomonas aeruginosa in complex with 5-(2- thienyl)-3-isoxazolyl methanol=== | ===Crystal Structure of 3-hydroxydecanoyl-Acyl Carrier Protein Dehydratase (FabA) from Pseudomonas aeruginosa in complex with 5-(2- thienyl)-3-isoxazolyl methanol=== | ||
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{{ABSTRACT_PUBMED_23174186}} | {{ABSTRACT_PUBMED_23174186}} | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/FABA_PSEAE FABA_PSEAE]] Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length (By similarity). | ||
==About this Structure== | ==About this Structure== | ||
[[4b0j]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B0J OCA]. | [[4b0j]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B0J OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023174186</ref><references group="xtra"/><references/> | ||
[[Category: Pseudomonas aeruginosa pao1]] | [[Category: Pseudomonas aeruginosa pao1]] | ||
[[Category: Duthie, F G.]] | [[Category: Duthie, F G.]] | ||
| - | [[Category: | + | [[Category: McMahon, S A.]] |
[[Category: Moynie, L.]] | [[Category: Moynie, L.]] | ||
[[Category: Naismith, J H.]] | [[Category: Naismith, J H.]] | ||
Revision as of 08:49, 4 September 2013
Contents |
Crystal Structure of 3-hydroxydecanoyl-Acyl Carrier Protein Dehydratase (FabA) from Pseudomonas aeruginosa in complex with 5-(2- thienyl)-3-isoxazolyl methanol
Template:ABSTRACT PUBMED 23174186
Function
[FABA_PSEAE] Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length (By similarity).
About this Structure
4b0j is a 20 chain structure with sequence from Pseudomonas aeruginosa pao1. Full crystallographic information is available from OCA.
Reference
- Moynie L, Leckie SM, McMahon SA, Duthie FG, Koehnke A, Taylor JW, Alphey MS, Brenk R, Smith AD, Naismith JH. Structural Insights into the Mechanism and Inhibition of the beta-Hydroxydecanoyl-Acyl Carrier Protein Dehydratase from Pseudomonasaeruginosa. J Mol Biol. 2013 Jan 23;425(2):365-77. doi: 10.1016/j.jmb.2012.11.017. Epub 2012 , Nov 19. PMID:23174186 doi:10.1016/j.jmb.2012.11.017
