4hjc
From Proteopedia
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| - | [[ | + | ==Crystal structure of glycoprotein C from Rift Valley Fever Virus (non-glycosylated)== |
| + | <StructureSection load='4hjc' size='340' side='right' caption='[[4hjc]], [[Resolution|resolution]] 4.15Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4hjc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rift_valley_fever_virus Rift valley fever virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HJC FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4hj1|4hj1]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hjc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hjc RCSB], [http://www.ebi.ac.uk/pdbsum/4hjc PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Rift Valley fever virus (RVFV), like many other Bunyaviridae family members, is an emerging human and animal pathogen. Bunyaviruses have an outer lipid envelope bearing two glycoproteins, G(N) and G(C), required for cell entry. Bunyaviruses deliver their genome into the host-cell cytoplasm by fusing their envelope with an endosomal membrane. The molecular mechanism of this key entry step is unknown. The crystal structure of RVFV G(C) reveals a class II fusion protein architecture found previously in flaviviruses and alphaviruses. The structure identifies G(C) as the effector of membrane fusion and provides a direct view of the membrane anchor that initiates fusion. A structure of nonglycosylated G(C) reveals an extended conformation that may represent a fusion intermediate. Unanticipated similarities between G(C) and flavivirus envelope proteins reveal an evolutionary link between the two virus families and provide insights into the organization of G(C) in the outer shell of RVFV. | ||
| - | + | Crystal structure of glycoprotein C from Rift Valley fever virus.,Dessau M, Modis Y Proc Natl Acad Sci U S A. 2013 Jan 14. PMID:23319635<ref>PMID:23319635</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | == | + | __TOC__ |
| - | + | </StructureSection> | |
[[Category: Rift valley fever virus]] | [[Category: Rift valley fever virus]] | ||
| - | [[Category: Dessau, M | + | [[Category: Dessau, M]] |
| - | [[Category: Modis, Y | + | [[Category: Modis, Y]] |
[[Category: Class ii fusion protein]] | [[Category: Class ii fusion protein]] | ||
[[Category: Membrane fusion]] | [[Category: Membrane fusion]] | ||
Revision as of 12:46, 4 January 2015
Crystal structure of glycoprotein C from Rift Valley Fever Virus (non-glycosylated)
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