2m3n

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'''Unreleased structure'''
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{{STRUCTURE_2m3n| PDB=2m3n | SCENE= }}
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===Peptide leucine arginine===
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{{ABSTRACT_PUBMED_23988198}}
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The entry 2m3n is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/PLR_RANPI PLR_RANPI]] Mast cell degranulating peptide. Antiproliferative activity against human breast and ovarian tumor cell lines in vitro. Inhibits granulopoiesis in rat in vitro. Causes histamine release from rat peritoneal mast cells in vitro. Has antibacterial activity against Gram-positive bacteria B.megaterium Bm11, S.lentus and M.luteus, and antifungal activity against C.tropicalis, C.guiller-mondii and P.nicotianae spores. Has hemolytic activity. The mature peptide inserts into the hydrophobic core of the bacterial cell membrane and increases permeability without disrupting membrane integrity. Probably binds to the outer membrane surface before aggregating to form transmembrane pores.<ref>PMID:11099505</ref> <ref>PMID:9673585</ref> <ref>PMID:14636071</ref>
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Authors: Polte, T.
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==About this Structure==
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[[2m3n]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M3N OCA].
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Description: Peptide leucine arginine
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==Reference==
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<ref group="xtra">PMID:023988198</ref><references group="xtra"/><references/>
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[[Category: Polte, T.]]
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[[Category: Bowman birk inhibitor]]
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[[Category: Hydrolase inhibitor]]

Revision as of 05:19, 12 September 2013

Template:STRUCTURE 2m3n

Contents

Peptide leucine arginine

Template:ABSTRACT PUBMED 23988198

Function

[PLR_RANPI] Mast cell degranulating peptide. Antiproliferative activity against human breast and ovarian tumor cell lines in vitro. Inhibits granulopoiesis in rat in vitro. Causes histamine release from rat peritoneal mast cells in vitro. Has antibacterial activity against Gram-positive bacteria B.megaterium Bm11, S.lentus and M.luteus, and antifungal activity against C.tropicalis, C.guiller-mondii and P.nicotianae spores. Has hemolytic activity. The mature peptide inserts into the hydrophobic core of the bacterial cell membrane and increases permeability without disrupting membrane integrity. Probably binds to the outer membrane surface before aggregating to form transmembrane pores.[1] [2] [3]

About this Structure

2m3n is a 1 chain structure. Full experimental information is available from OCA.

Reference

  • Rothemund S, Sonnichsen FD, Polte T. Therapeutic Potential of the Peptide Leucine Arginine As a New Nonplant Bowman-Birk-Like Serine Protease Inhibitor. J Med Chem. 2013 Aug 29. PMID:23988198 doi:10.1021/jm4005362
  1. ↑ Salmon AL, Cross LJ, Irvine AE, Lappin TR, Dathe M, Krause G, Canning P, Thim L, Beyermann M, Rothemund S, Bienert M, Shaw C. Peptide leucine arginine, a potent immunomodulatory peptide isolated and structurally characterized from the skin of the Northern Leopard frog, Rana pipiens. J Biol Chem. 2001 Mar 30;276(13):10145-52. Epub 2000 Nov 30. PMID:11099505 doi:10.1074/jbc.M009680200
  2. ↑ . Joint British Association and Irish Association Cancer Research Meeting. Dublin, Ireland, 21-24 June 1998. Abstracts. Br J Cancer. 1998;78 Suppl 1:1-78. PMID:9673585
  3. ↑ Mangoni ML, Papo N, Mignogna G, Andreu D, Shai Y, Barra D, Simmaco M. Ranacyclins, a new family of short cyclic antimicrobial peptides: biological function, mode of action, and parameters involved in target specificity. Biochemistry. 2003 Dec 2;42(47):14023-35. PMID:14636071 doi:10.1021/bi034521l

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