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3w58

From Proteopedia

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m (Protected "3w58" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_3w58| PDB=3w58 | SCENE= }}
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===Crystal structure of Galectin-1 in the lactose-unbound state(P21)===
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The entry 3w58 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/LEG1_HUMAN LEG1_HUMAN]] May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.<ref>PMID:14617626</ref> <ref>PMID:18796645</ref>
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Authors: Saburi, H., Tanaka, T., Kunishima, N.
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==About this Structure==
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[[3w58]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W58 OCA].
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Description: Crystal structure of Galectin-1 in the lactose-unbound state(P21)
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Kunishima, N.]]
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[[Category: Saburi, H.]]
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[[Category: Tanaka, T.]]
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[[Category: Galectin]]
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[[Category: Lactose unbound state]]
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[[Category: Lectin]]
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[[Category: Sugar binding protein]]

Revision as of 07:42, 29 January 2014

Template:STRUCTURE 3w58

Contents

Crystal structure of Galectin-1 in the lactose-unbound state(P21)

Function

[LEG1_HUMAN] May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.[1] [2]

About this Structure

3w58 is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ He J, Baum LG. Presentation of galectin-1 by extracellular matrix triggers T cell death. J Biol Chem. 2004 Feb 6;279(6):4705-12. Epub 2003 Nov 14. PMID:14617626 doi:10.1074/jbc.M311183200
  2. ↑ Nishi N, Abe A, Iwaki J, Yoshida H, Itoh A, Shoji H, Kamitori S, Hirabayashi J, Nakamura T. Functional and structural bases of a cysteine-less mutant as a long-lasting substitute for galectin-1. Glycobiology. 2008 Dec;18(12):1065-73. Epub 2008 Sep 16. PMID:18796645 doi:10.1093/glycob/cwn089

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