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1zkz
From Proteopedia
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| - | [[Image:1zkz.gif|left|200px]] | + | [[Image:1zkz.gif|left|200px]] |
| - | + | ||
| - | '''Crystal Structure of BMP9''' | + | {{Structure |
| + | |PDB= 1zkz |SIZE=350|CAPTION= <scene name='initialview01'>1zkz</scene>, resolution 2.33Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= GDF2, BMP9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal Structure of BMP9''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1ZKZ is a [ | + | 1ZKZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZKZ OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of BMP-9 and functional interactions with pro-region and receptors., Brown MA, Zhao Q, Baker KA, Naik C, Chen C, Pukac L, Singh M, Tsareva T, Parice Y, Mahoney A, Roschke V, Sanyal I, Choe S, J Biol Chem. 2005 Jul 1;280(26):25111-8. Epub 2005 Apr 25. PMID:[http:// | + | Crystal structure of BMP-9 and functional interactions with pro-region and receptors., Brown MA, Zhao Q, Baker KA, Naik C, Chen C, Pukac L, Singh M, Tsareva T, Parice Y, Mahoney A, Roschke V, Sanyal I, Choe S, J Biol Chem. 2005 Jul 1;280(26):25111-8. Epub 2005 Apr 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15851468 15851468] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: signal]] | [[Category: signal]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:36:48 2008'' |
Revision as of 13:36, 20 March 2008
| |||||||
| , resolution 2.33Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | GDF2, BMP9 (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of BMP9
Overview
Bone morphogenetic proteins (BMPs), a subset of the transforming growth factor (TGF)-beta superfamily, regulate a diverse array of cellular functions during development and in the adult. BMP-9 (also known as growth and differentiation factor (GDF)-2) potently induces osteogenesis and chondrogenesis, has been implicated in the differentiation of cholinergic neurons, and may help regulate glucose metabolism. We have determined the structure of BMP-9 to 2.3 A and examined the differences between our model and existing crystal structures of other BMPs, both in isolation and in complex with their receptors. TGF-beta ligands are translated as precursors, with pro-regions that generally dissociate after cleavage from the ligand, but in some cases (including GDF-8 and TGF-beta1, -2, and -3), the pro-region remains associated after secretion from the cell and inhibits binding of the ligand to its receptor. Although the proregion of BMP-9 remains tightly associated after secretion, we find, in several cell-based assays, that the activities of BMP-9 and BMP-9.pro-region complex were equivalent. Activin receptor-like kinase 1 (ALK-1), an orphan receptor in the TGF-beta family, was also identified as a potential receptor for BMP-9 based on surface plasmon resonance studies (BIAcore) and the ability of soluble ALK-1 to block the activity of BMP-9.pro-region complex in cell-based assays.
About this Structure
1ZKZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of BMP-9 and functional interactions with pro-region and receptors., Brown MA, Zhao Q, Baker KA, Naik C, Chen C, Pukac L, Singh M, Tsareva T, Parice Y, Mahoney A, Roschke V, Sanyal I, Choe S, J Biol Chem. 2005 Jul 1;280(26):25111-8. Epub 2005 Apr 25. PMID:15851468
Page seeded by OCA on Thu Mar 20 15:36:48 2008
Categories: Homo sapiens | Single protein | Baker, K A. | Brown, M A. | Chen, C. | Choe, S. | Mahoney, A. | Naik, C. | Parice, Y. | Pukac, L. | Roschke, V. | Sanyal, I. | Singh, M. | Tsareva, T. | Zhao, Q. | Cytokine | Glycoprotein | Growth factor | Signal
