1zld
From Proteopedia
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| - | [[Image:1zld.gif|left|200px]] | + | [[Image:1zld.gif|left|200px]] |
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| - | '''Crystal structure of a RGD-containing host-selective toxin: Pyrenophora tritici-repentis Ptr ToxA''' | + | {{Structure |
| + | |PDB= 1zld |SIZE=350|CAPTION= <scene name='initialview01'>1zld</scene>, resolution 1.65Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of a RGD-containing host-selective toxin: Pyrenophora tritici-repentis Ptr ToxA''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1ZLD is a [ | + | 1ZLD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrenophora_tritici-repentis Pyrenophora tritici-repentis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZLD OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of Ptr ToxA: an RGD-containing host-selective toxin from Pyrenophora tritici-repentis., Sarma GN, Manning VA, Ciuffetti LM, Karplus PA, Plant Cell. 2005 Nov;17(11):3190-202. Epub 2005 Oct 7. PMID:[http:// | + | Structure of Ptr ToxA: an RGD-containing host-selective toxin from Pyrenophora tritici-repentis., Sarma GN, Manning VA, Ciuffetti LM, Karplus PA, Plant Cell. 2005 Nov;17(11):3190-202. Epub 2005 Oct 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16214901 16214901] |
[[Category: Pyrenophora tritici-repentis]] | [[Category: Pyrenophora tritici-repentis]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: beta-sandwich; rgd-motif]] | [[Category: beta-sandwich; rgd-motif]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:36:54 2008'' |
Revision as of 13:36, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of a RGD-containing host-selective toxin: Pyrenophora tritici-repentis Ptr ToxA
Overview
Tan spot of wheat (Triticum aestivum), caused by the fungus Pyrenophora tritici-repentis, has significant agricultural and economic impact. Ptr ToxA (ToxA), the first discovered proteinaceous host-selective toxin, is produced by certain P. tritici-repentis races and is necessary and sufficient to cause cell death in sensitive wheat cultivars. We present here the high-resolution crystal structure of ToxA in two different crystal forms, providing four independent views of the protein. ToxA adopts a single-domain, beta-sandwich fold of novel topology. Mapping of the existing mutation data onto the structure supports the hypothesized importance of an Arg-Gly-Asp (RGD) and surrounding sequence. Its occurrence in a single, solvent-exposed loop in the protein suggests that it is directly involved in recognition events required for ToxA action. Furthermore, the ToxA structure reveals a surprising similarity with the classic mammalian RGD-containing domain, the fibronectin type III (FnIII) domain: the two topologies are related by circular permutation. The similar topologies and the positional conservation of the RGD-containing loop raises the possibility that ToxA is distantly related to mammalian FnIII proteins and that to gain entry it binds to an integrin-like receptor in the plant host.
About this Structure
1ZLD is a Single protein structure of sequence from Pyrenophora tritici-repentis. Full crystallographic information is available from OCA.
Reference
Structure of Ptr ToxA: an RGD-containing host-selective toxin from Pyrenophora tritici-repentis., Sarma GN, Manning VA, Ciuffetti LM, Karplus PA, Plant Cell. 2005 Nov;17(11):3190-202. Epub 2005 Oct 7. PMID:16214901
Page seeded by OCA on Thu Mar 20 15:36:54 2008
