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3eum

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[[Image:3eum.png|left|200px]]
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==A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine BSU-6066==
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<StructureSection load='3eum' size='340' side='right' caption='[[3eum]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3eum]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EUM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EUM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NCQ:3,6-BIS[3-(AZEPAN-1-YL)PROPIONAMIDO]ACRIDINE'>NCQ</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1l1h|1l1h]], [[1jpq|1jpq]], [[1jrn|1jrn]], [[3ce5|3ce5]], [[3em2|3em2]], [[3eqw|3eqw]], [[3eru|3eru]], [[3es0|3es0]], [[3et8|3et8]], [[3eui|3eui]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eum OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eum RCSB], [http://www.ebi.ac.uk/pdbsum/3eum PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A series of disubstituted acridine ligands have been cocrystallized with a bimolecular DNA G-quadruplex. The ligands have a range of cyclic amino end groups of varying size. The crystal structures show that the diagonal loop in this quadruplex results in a large cavity for these groups, in contrast to the steric constraints imposed by propeller loops in human telomeric quadruplexes. We conclude that the nature of the loop has a significant influence on ligand selectivity for particular quadruplex folds.
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{{STRUCTURE_3eum| PDB=3eum | SCENE= }}
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Selectivity in Ligand Recognition of G-Quadruplex Loops (dagger).,Campbell NH, Patel M, Tofa AB, Ghosh R, Parkinson GN, Neidle S Biochemistry. 2009 Feb 4. PMID:19173611<ref>PMID:19173611</ref>
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===A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine BSU-6066===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_19173611}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3eum]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EUM OCA].
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</StructureSection>
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[[Category: Campbell, N H]]
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==Reference==
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[[Category: Neidle, S]]
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<ref group="xtra">PMID:019173611</ref><references group="xtra"/>
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[[Category: Parkinson, G]]
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[[Category: Campbell, N H.]]
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[[Category: Neidle, S.]]
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[[Category: Parkinson, G.]]
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[[Category: Anti-parallel]]
[[Category: Anti-parallel]]
[[Category: Bimolecular]]
[[Category: Bimolecular]]

Revision as of 08:46, 26 November 2014

A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine BSU-6066

3eum, resolution 1.78Å

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