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3zm5

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_3zm5| PDB=3zm5 | SCENE= }}
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===CRYSTAL STRUCTURE OF MURF LIGASE IN COMPLEX WITH CYANOTHIOPHENE INHIBITOR===
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{{ABSTRACT_PUBMED_23786712}}
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The entry 3zm5 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/Q8DNV6_STRR6 Q8DNV6_STRR6]] Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity).[RuleBase:RU004136]
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Authors: Hrast, M., Turk, S., Sosic, I., Knez, D., Randall, C.P., Barreteau, H., Contreras-Martel, C., Dessen, A., ONeill, A.J., Mengin-Lecreulx, D., Blanot, D., Gobec, S.
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==About this Structure==
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[[3zm5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae_r6 Streptococcus pneumoniae r6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZM5 OCA].
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Description: CRYSTAL STRUCTURE OF MURF LIGASE IN COMPLEX WITH CYANOTHIOPHENE INHIBITOR
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==Reference==
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<ref group="xtra">PMID:023786712</ref><references group="xtra"/><references/>
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[[Category: Streptococcus pneumoniae r6]]
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[[Category: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase]]
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[[Category: Barreteau, H.]]
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[[Category: Blanot, D.]]
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[[Category: Contreras-Martel, C.]]
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[[Category: Dessen, A.]]
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[[Category: Gobec, S.]]
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[[Category: Hrast, M.]]
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[[Category: Knez, D.]]
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[[Category: Mengin-Lecreulx, D.]]
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[[Category: ONeill, A J.]]
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[[Category: Randall, C P.]]
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[[Category: Sosic, I.]]
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[[Category: Turk, S.]]
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[[Category: Adp-forming enzyme]]
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[[Category: Atp-binding]]
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[[Category: Cell cycle]]
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[[Category: Cell divison]]
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[[Category: Cell shape]]
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[[Category: Cell wall]]
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[[Category: Ligase]]
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[[Category: Nucleotide-binding]]
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[[Category: Peptidoglycan synthesis]]

Revision as of 14:09, 3 July 2013

Template:STRUCTURE 3zm5

Contents

CRYSTAL STRUCTURE OF MURF LIGASE IN COMPLEX WITH CYANOTHIOPHENE INHIBITOR

Template:ABSTRACT PUBMED 23786712

Function

[Q8DNV6_STRR6] Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity).[RuleBase:RU004136]

About this Structure

3zm5 is a 1 chain structure with sequence from Streptococcus pneumoniae r6. Full crystallographic information is available from OCA.

Reference

  • Hrast M, Turk S, Sosic I, Knez D, Randall CP, Barreteau H, Contreras-Martel C, Dessen A, O'Neill AJ, Mengin-Lecreulx D, Blanot D, Gobec S. Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF. Eur J Med Chem. 2013 May 21;66C:32-45. doi: 10.1016/j.ejmech.2013.05.013. PMID:23786712 doi:10.1016/j.ejmech.2013.05.013

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OCA

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