4hra

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'''Unreleased structure'''
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{{STRUCTURE_4hra| PDB=4hra | SCENE= }}
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===Crystal Structure of DOT1L in Complex with EPZ-5676===
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{{ABSTRACT_PUBMED_23801631}}
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The entry 4hra is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN]] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
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Authors: Jin, L.
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==About this Structure==
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[[4hra]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HRA OCA].
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Description: Crystal Structure of DOT1L in Complex with EPZ-5676
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==Reference==
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<ref group="xtra">PMID:023801631</ref><references group="xtra"/><references/>
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[[Category: Histone-lysine N-methyltransferase]]
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[[Category: Homo sapiens]]
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[[Category: Jin, L.]]
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[[Category: Histone lysine methyltransferase]]
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[[Category: Transferase]]
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[[Category: Transferase-transferase inhibitor complex]]

Revision as of 05:18, 1 August 2013

Template:STRUCTURE 4hra

Contents

Crystal Structure of DOT1L in Complex with EPZ-5676

Template:ABSTRACT PUBMED 23801631

Function

[DOT1L_HUMAN] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.

About this Structure

4hra is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Daigle SR, Olhava EJ, Therkelsen CA, Basavapathruni A, Jin L, Boriack-Sjodin PA, Allain CJ, Klaus CR, Raimondi A, Scott MP, Waters NJ, Chesworth R, Moyer MP, Copeland RA, Richon VM, Pollock RM. Potent inhibition of DOT1L as treatment for MLL-fusion leukemia. Blood. 2013 Jun 25. PMID:23801631 doi:10.1182/blood-2013-04-497644

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OCA

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