1zww
From Proteopedia
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| - | [[Image:1zww.gif|left|200px]] | + | [[Image:1zww.gif|left|200px]] |
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| - | '''Crystal structure of endophilin-A1 BAR domain''' | + | {{Structure |
| + | |PDB= 1zww |SIZE=350|CAPTION= <scene name='initialview01'>1zww</scene>, resolution 2.30Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=CD:CADMIUM ION'>CD</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= Sh3gl2, Sh3d2a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of endophilin-A1 BAR domain''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1ZWW is a [ | + | 1ZWW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZWW OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the endophilin-A1 BAR domain., Weissenhorn W, J Mol Biol. 2005 Aug 19;351(3):653-61. PMID:[http:// | + | Crystal structure of the endophilin-A1 BAR domain., Weissenhorn W, J Mol Biol. 2005 Aug 19;351(3):653-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16023669 16023669] |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: coiled coil]] | [[Category: coiled coil]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:40:48 2008'' |
Revision as of 13:40, 20 March 2008
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| , resolution 2.30Å | |||||||
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| Ligands: | |||||||
| Gene: | Sh3gl2, Sh3d2a (Mus musculus) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of endophilin-A1 BAR domain
Overview
Endophilin has been implicated in the retrieval of membrane via endocytosis of clathrin-coated vesicles, which is crucial for the maintenance of neurotransmitter exocytosis during stimulation; both exocytosis and endocytosis are regulated by intracellular calcium levels. Here, we present the 2.3 A crystal structure of the endophilin-A1 BAR domain, which has been suggested to function in inducing and sensing membrane curvature at the site of endocytosis. Endo-BAR folds into a crescent-shaped dimer composed of two elongated, three-helix bundles. Two additional domains of 30 residues each, inserted into helix 1 at the center of the concave side of the dimer, may interfere with the proposed mode of BAR domain membrane interaction. In addition, the dimer binds 11 divalent cadmium ions in the crystal mostly with typical Ca2+ co-ordination spheres. The endophilin-1A BAR domain thus constitutes a new variant of a BAR domain, and it may link endophilin-1A BAR function to calcium regulation of endocytosis.
About this Structure
1ZWW is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of the endophilin-A1 BAR domain., Weissenhorn W, J Mol Biol. 2005 Aug 19;351(3):653-61. PMID:16023669
Page seeded by OCA on Thu Mar 20 15:40:48 2008
