4iof

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'''Unreleased structure'''
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{{STRUCTURE_4iof| PDB=4iof | SCENE= }}
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===Crystal structure analysis of Fab-bound human Insulin Degrading Enzyme (IDE)===
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The entry 4iof is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref>
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Authors: McCord, L.A., Liang, W.G, Hoey, R., Dowdell, E., Koide, A., Koide, S., Tang, W.J.
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==About this Structure==
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[[4iof]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IOF OCA].
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Description: Crystal structure analysis of Fab-bound human Insulin Degrading Enzyme (IDE)
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Insulysin]]
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[[Category: Mus musculus]]
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[[Category: Dowdell, E.]]
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[[Category: Hoey, R.]]
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[[Category: Koide, A.]]
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[[Category: Koide, S.]]
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[[Category: Liang, W G]]
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[[Category: McCord, L A.]]
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[[Category: Tang, W J.]]
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[[Category: Hydrolase]]
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[[Category: Zinc metalloprotease]]

Revision as of 13:11, 24 July 2013

Template:STRUCTURE 4iof

Contents

Crystal structure analysis of Fab-bound human Insulin Degrading Enzyme (IDE)

Function

[IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.[1] [2] [3]

About this Structure

4iof is a 6 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

  1. ↑ Vekrellis K, Ye Z, Qiu WQ, Walsh D, Hartley D, Chesneau V, Rosner MR, Selkoe DJ. Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme. J Neurosci. 2000 Mar 1;20(5):1657-65. PMID:10684867
  2. ↑ Im H, Manolopoulou M, Malito E, Shen Y, Zhao J, Neant-Fery M, Sun CY, Meredith SC, Sisodia SS, Leissring MA, Tang WJ. Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE. J Biol Chem. 2007 Aug 31;282(35):25453-63. Epub 2007 Jul 5. PMID:17613531 doi:10.1074/jbc.M701590200
  3. ↑ Malito E, Ralat LA, Manolopoulou M, Tsay JL, Wadlington NL, Tang WJ. Molecular Bases for the Recognition of Short Peptide Substrates and Cysteine-Directed Modifications of Human Insulin-Degrading Enzyme. Biochemistry. 2008 Nov 6. PMID:18986166 doi:10.1021/bi801192h

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