4is8

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'''Unreleased structure'''
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{{STRUCTURE_4is8| PDB=4is8 | SCENE= }}
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===Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors===
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The entry 4is8 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/NR5A2_HUMAN NR5A2_HUMAN]] Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
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Authors: Musille, P.M., Pathak, M.C., Ortlund, E.A.
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==About this Structure==
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[[4is8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IS8 OCA].
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Description: A six-residue insertion in the human lrh-1 is sufficient to induce the active conformation in the absence of ligand
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[[Category: Homo sapiens]]
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[[Category: Musille, P M.]]
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[[Category: Ortlund, E A.]]
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[[Category: Pathak, M C.]]
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[[Category: Ligand binding domain]]
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[[Category: Transcription]]

Revision as of 21:04, 19 June 2013

Template:STRUCTURE 4is8

Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors

Function

[NR5A2_HUMAN] Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.

About this Structure

4is8 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

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OCA

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