3vep
From Proteopedia
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{{STRUCTURE_3vep| PDB=3vep | SCENE= }} | {{STRUCTURE_3vep| PDB=3vep | SCENE= }} | ||
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===Crystal structure of SigD4 in complex with its negative regulator RsdA=== | ===Crystal structure of SigD4 in complex with its negative regulator RsdA=== | ||
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{{ABSTRACT_PUBMED_23314154}} | {{ABSTRACT_PUBMED_23314154}} | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/RPSD_MYCTU RPSD_MYCTU]] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis.<ref>PMID:15375142</ref> | ||
==About this Structure== | ==About this Structure== | ||
[[3vep]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VEP OCA]. | [[3vep]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VEP OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023314154</ref><references group="xtra"/><references/> | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: Gopal, B.]] | [[Category: Gopal, B.]] | ||
Revision as of 05:07, 10 October 2013
Contents |
Crystal structure of SigD4 in complex with its negative regulator RsdA
Template:ABSTRACT PUBMED 23314154
Function
[RPSD_MYCTU] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis.[1]
About this Structure
3vep is a 8 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.
Reference
- Jaiswal RK, Prabha TS, Manjeera G, Gopal B. Mycobacterium tuberculosis RsdA provides a conformational rationale for selective regulation of sigma-factor activity by proteolysis. Nucleic Acids Res. 2013 Jan 11. PMID:23314154 doi:http://dx.doi.org/10.1093/nar/gks1468
- ↑ Raman S, Hazra R, Dascher CC, Husson RN. Transcription regulation by the Mycobacterium tuberculosis alternative sigma factor SigD and its role in virulence. J Bacteriol. 2004 Oct;186(19):6605-16. PMID:15375142 doi:http://dx.doi.org/10.1128/JB.186.19.6605-6616.2004
