2a0t
From Proteopedia
(Difference between revisions)
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| - | [[Image:2a0t.gif|left|200px]] | + | [[Image:2a0t.gif|left|200px]] |
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| - | '''NMR structure of the FHA1 domain of Rad53 in complex with a biological relevant phosphopeptide derived from Madt1''' | + | {{Structure |
| + | |PDB= 2a0t |SIZE=350|CAPTION= <scene name='initialview01'>2a0t</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] | ||
| + | |GENE= SPK1 or Rad53 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]) | ||
| + | }} | ||
| + | |||
| + | '''NMR structure of the FHA1 domain of Rad53 in complex with a biological relevant phosphopeptide derived from Madt1''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2A0T is a [ | + | 2A0T is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A0T OCA]. |
==Reference== | ==Reference== | ||
| - | FHA domain-ligand interactions: importance of integrating chemical and biological approaches., Mahajan A, Yuan C, Pike BL, Heierhorst J, Chang CF, Tsai MD, J Am Chem Soc. 2005 Oct 26;127(42):14572-3. PMID:[http:// | + | FHA domain-ligand interactions: importance of integrating chemical and biological approaches., Mahajan A, Yuan C, Pike BL, Heierhorst J, Chang CF, Tsai MD, J Am Chem Soc. 2005 Oct 26;127(42):14572-3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16231900 16231900] |
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: phosphothreonine]] | [[Category: phosphothreonine]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:44:03 2008'' |
Revision as of 13:44, 20 March 2008
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| Gene: | SPK1 or Rad53 (Saccharomyces cerevisiae) | ||||||
| Activity: | Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
NMR structure of the FHA1 domain of Rad53 in complex with a biological relevant phosphopeptide derived from Madt1
Overview
Combinatorial library screens based on binding affinity may preferentially select ligands with ability for ionic interactions and miss the biologically relevant ligands that bind more weakly with predominantly hydrophobic interactions.
About this Structure
2A0T is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
FHA domain-ligand interactions: importance of integrating chemical and biological approaches., Mahajan A, Yuan C, Pike BL, Heierhorst J, Chang CF, Tsai MD, J Am Chem Soc. 2005 Oct 26;127(42):14572-3. PMID:16231900
Page seeded by OCA on Thu Mar 20 15:44:03 2008
