4idl
From Proteopedia
(Difference between revisions)
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| - | [[ | + | ==Low melting temperature Anti-Cholera Toxin Llama VHH domain== |
| + | <StructureSection load='4idl' size='340' side='right' caption='[[4idl]], [[Resolution|resolution]] 2.09Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4idl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IDL FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4idl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4idl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4idl RCSB], [http://www.ebi.ac.uk/pdbsum/4idl PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Variable heavy domains derived from the heavy-chain-only antibodies found in camelids (V(H)H domains) are known for their thermal stability. Here, the structure of A9, an anti-cholera toxin V(H)H domain (K(d) = 77 +/- 5 nM) that has an unusually low melting temperature of 319.9 +/- 1.6 K, is reported. The CDR3 residues of A9 form a beta-hairpin that is directed away from the former V(H)-V(L) interfacial surface, exposing hydrophobic residues to the solvent. A DALI structural similarity search showed that this CDR3 conformation is uncommon. | ||
| - | + | Structure of a low-melting-temperature anti-cholera toxin: llama V(H)H domain.,Legler PM, Zabetakis D, Anderson GP, Lam A, Hol WG, Goldman ER Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Feb 1;69(Pt 2):90-3. doi: , 10.1107/S1744309112050750. Epub 2013 Jan 26. PMID:23385744<ref>PMID:23385744</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| - | + | ==See Also== | |
| - | + | *[[Monoclonal Antibody|Monoclonal Antibody]] | |
| - | == | + | == References == |
| - | [[ | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Lama glama]] | [[Category: Lama glama]] | ||
| - | [[Category: Hol, W G.J | + | [[Category: Hol, W G.J]] |
| - | [[Category: Lam, A | + | [[Category: Lam, A]] |
| - | [[Category: Legler, P M | + | [[Category: Legler, P M]] |
[[Category: Antibody]] | [[Category: Antibody]] | ||
[[Category: Cholera toxin]] | [[Category: Cholera toxin]] | ||
Revision as of 17:01, 10 December 2014
Low melting temperature Anti-Cholera Toxin Llama VHH domain
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