2a2j

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[[Image:2a2j.gif|left|200px]]<br /><applet load="2a2j" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2a2j.gif|left|200px]]
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caption="2a2j, resolution 2.50&Aring;" />
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'''Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis'''<br />
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{{Structure
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|PDB= 2a2j |SIZE=350|CAPTION= <scene name='initialview01'>2a2j</scene>, resolution 2.50&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY= [http://en.wikipedia.org/wiki/Pyridoxal_5'-phosphate_synthase Pyridoxal 5'-phosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.5 1.4.3.5]
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|GENE=
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}}
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'''Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2A2J is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Active as [http://en.wikipedia.org/wiki/Pyridoxal_5'-phosphate_synthase Pyridoxal 5'-phosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.5 1.4.3.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2J OCA].
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2A2J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2J OCA].
==Reference==
==Reference==
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Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis., Pedelacq JD, Rho BS, Kim CY, Waldo GS, Lekin TP, Segelke BW, Rupp B, Hung LW, Kim SI, Terwilliger TC, Proteins. 2006 Mar 15;62(3):563-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16374842 16374842]
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Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis., Pedelacq JD, Rho BS, Kim CY, Waldo GS, Lekin TP, Segelke BW, Rupp B, Hung LW, Kim SI, Terwilliger TC, Proteins. 2006 Mar 15;62(3):563-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16374842 16374842]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Pyridoxal 5'-phosphate synthase]]
[[Category: Pyridoxal 5'-phosphate synthase]]
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[[Category: beta barrel]]
[[Category: beta barrel]]
[[Category: mycobacterium tuberculosis structural proteomics project]]
[[Category: mycobacterium tuberculosis structural proteomics project]]
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[[Category: structural genomics]]
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[[Category: structural genomic]]
[[Category: xmtb]]
[[Category: xmtb]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:23:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:44:40 2008''

Revision as of 13:44, 20 March 2008

Image:2a2j.gif


PDB ID 2a2j

Drag the structure with the mouse to rotate
, resolution 2.50Å
Activity: Pyridoxal 5'-phosphate synthase, with EC number 1.4.3.5
Coordinates: save as pdb, mmCIF, xml



Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis


Overview

The three-dimensional structure of Rv2607, a putative pyridoxine 5'-phosphate oxidase (PNPOx) from Mycobacterium tuberculosis, has been determined by X-ray crystallography to 2.5 A resolution. Rv2607 has a core domain similar to known PNPOx structures with a flavin mononucleotide (FMN) cofactor. Electron density for two FMN at the dimer interface is weak despite the bright yellow color of the protein solution and crystal. The shape and size of the putative binding pocket is markedly different from that of members of the PNPOx family, which may indicate some significant changes in the FMN binding mode of this protein relative to members of the family.

About this Structure

2A2J is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis., Pedelacq JD, Rho BS, Kim CY, Waldo GS, Lekin TP, Segelke BW, Rupp B, Hung LW, Kim SI, Terwilliger TC, Proteins. 2006 Mar 15;62(3):563-9. PMID:16374842

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