4i1p
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==protease bound to tetrapeptide== |
| - | + | <StructureSection load='4i1p' size='340' side='right' caption='[[4i1p]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4i1p]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I1P FirstGlance]. <br> | |
| - | + | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene><br> | |
| - | + | <tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=4AR:AMINO({(4S)-4-AMINO-6-[(2,6-DIMETHYLBENZOYL)OXY]-5-OXOHEXYL}AMINO)METHANIMINIUM'>4AR</scene></td></tr> | |
| - | + | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4i1r|4i1r]]</td></tr> | |
| + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i1p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4i1p RCSB], [http://www.ebi.ac.uk/pdbsum/4i1p PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN]] Note=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN]] Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.<ref>PMID:11262391</ref> <ref>PMID:14695475</ref> <ref>PMID:18264101</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Hopfner, K P.]] | ||
| + | [[Category: Lammens, K.]] | ||
| + | [[Category: Schlauderer, F.]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Protease]] | ||
Revision as of 07:30, 9 July 2014
protease bound to tetrapeptide
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