4j36

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'''Unreleased structure'''
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{{STRUCTURE_4j36| PDB=4j36 | SCENE= }}
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===Cocrystal Structure of kynurenine 3-monooxygenase in complex with UPF 648 inhibitor(KMO-394UPF)===
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The entry 4j36 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/KMO_YEAST KMO_YEAST]] Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.<ref>PMID:12062417</ref> <ref>PMID:15806102</ref>
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Authors: Amaral, M., Levy, C., Heyes, D.J., Lafite, P., Outeiro, T.F., Giorgini, F., Leys, D., Scrutton, N.S.
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==About this Structure==
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[[4j36]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J36 OCA].
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Description: Cocrystal Structure of kynurenine 3-monooxygenase in complex with UPF 648 inhibitor(KMO-394UPF)
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Kynurenine 3-monooxygenase]]
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[[Category: Saccharomyces cerevisiae s288c]]
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[[Category: Amaral, M.]]
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[[Category: Giorgini, F.]]
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[[Category: Heyes, D J.]]
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[[Category: Lafite, P.]]
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[[Category: Levy, C.]]
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[[Category: Leys, D.]]
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[[Category: Outeiro, T F.]]
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[[Category: Scrutton, N S.]]
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[[Category: Monooxygenase kynurenine upf 648]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

Revision as of 22:49, 10 April 2013

Template:STRUCTURE 4j36

Contents

Cocrystal Structure of kynurenine 3-monooxygenase in complex with UPF 648 inhibitor(KMO-394UPF)

Function

[KMO_YEAST] Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.[1] [2]

About this Structure

4j36 is a 2 chain structure with sequence from Saccharomyces cerevisiae s288c. Full crystallographic information is available from OCA.

Reference

  1. ↑ Panozzo C, Nawara M, Suski C, Kucharczyka R, Skoneczny M, Becam AM, Rytka J, Herbert CJ. Aerobic and anaerobic NAD+ metabolism in Saccharomyces cerevisiae. FEBS Lett. 2002 Apr 24;517(1-3):97-102. PMID:12062417
  2. ↑ Giorgini F, Guidetti P, Nguyen Q, Bennett SC, Muchowski PJ. A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease. Nat Genet. 2005 May;37(5):526-31. Epub 2005 Apr 3. PMID:15806102 doi:ng1542

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