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4hhs
From Proteopedia
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{{STRUCTURE_4hhs| PDB=4hhs | SCENE= }} | {{STRUCTURE_4hhs| PDB=4hhs | SCENE= }} | ||
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===Crystal Structure of fatty acid alpha-dioxygenase (Arabidopsis thaliana)=== | ===Crystal Structure of fatty acid alpha-dioxygenase (Arabidopsis thaliana)=== | ||
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{{ABSTRACT_PUBMED_23373518}} | {{ABSTRACT_PUBMED_23373518}} | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/DOX1_ARATH DOX1_ARATH]] Alpha-dioxygenase that catalyzes the primary oxygenation of fatty acids into oxylipins. Mediates a protection against oxidative stress and cell death, probably by generating some lipid-derived molecules. Promotes local and systemic plant defense in a salicylic acid (SA)-dependent manner, including the establishment of systemic acquired resistance (SAR) in response to incompatible interaction. Involved in a negative regulation of abscisic acid (ABA)-mediated signaling pathway.<ref>PMID:12060227</ref> <ref>PMID:10455113</ref> <ref>PMID:22199234</ref> | ||
==About this Structure== | ==About this Structure== | ||
[[4hhs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HHS OCA]. | [[4hhs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HHS OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023373518</ref><references group="xtra"/><references/> | ||
[[Category: Arabidopsis thaliana]] | [[Category: Arabidopsis thaliana]] | ||
[[Category: Goulah, C C.]] | [[Category: Goulah, C C.]] | ||
Revision as of 04:56, 28 August 2013
Contents |
Crystal Structure of fatty acid alpha-dioxygenase (Arabidopsis thaliana)
Template:ABSTRACT PUBMED 23373518
Function
[DOX1_ARATH] Alpha-dioxygenase that catalyzes the primary oxygenation of fatty acids into oxylipins. Mediates a protection against oxidative stress and cell death, probably by generating some lipid-derived molecules. Promotes local and systemic plant defense in a salicylic acid (SA)-dependent manner, including the establishment of systemic acquired resistance (SAR) in response to incompatible interaction. Involved in a negative regulation of abscisic acid (ABA)-mediated signaling pathway.[1] [2] [3]
About this Structure
4hhs is a 1 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.
Reference
- Goulah CC, Zhu G, Koszelak-Rosenblum M, Malkowski MG. The Crystal Structure of alpha-Dioxygenase Provides Insight into Diversity in the Cyclooxygenase-Peroxidase Superfamily. Biochemistry. 2013 Feb 14. PMID:23373518 doi:10.1021/bi400013k
- ↑ De Leon IP, Sanz A, Hamberg M, Castresana C. Involvement of the Arabidopsis alpha-DOX1 fatty acid dioxygenase in protection against oxidative stress and cell death. Plant J. 2002 Jan;29(1):61-2. PMID:12060227
- ↑ Hamberg M, Sanz A, Castresana C. alpha-oxidation of fatty acids in higher plants. Identification of a pathogen-inducible oxygenase (piox) as an alpha-dioxygenase and biosynthesis of 2-hydroperoxylinolenic acid. J Biol Chem. 1999 Aug 27;274(35):24503-13. PMID:10455113
- ↑ Vicente J, Cascon T, Vicedo B, Garcia-Agustin P, Hamberg M, Castresana C. Role of 9-lipoxygenase and alpha-dioxygenase oxylipin pathways as modulators of local and systemic defense. Mol Plant. 2012 Jul;5(4):914-28. doi: 10.1093/mp/ssr105. Epub 2011 Dec 22. PMID:22199234 doi:10.1093/mp/ssr105
