3ftj

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[[Image:3ftj.png|left|200px]]
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==Crystal structure of the periplasmic region of MacB from Actinobacillus actinomycetemcomitans==
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<StructureSection load='3ftj' size='340' side='right' caption='[[3ftj]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ftj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aggregatibacter_actinomycetemcomitans Aggregatibacter actinomycetemcomitans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FTJ FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">macB, MACB_ACTAC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=714 Aggregatibacter actinomycetemcomitans])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ftj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ftj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ftj RCSB], [http://www.ebi.ac.uk/pdbsum/3ftj PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ft/3ftj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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MacB is a noncanonic ABC-type transporter within Gram-negative bacteria, which is responsible both for the efflux of macrolide antibiotics and for the secretion of heat-stable enterotoxin II. In Escherichia coli, MacB requires the membrane fusion protein MacA and the multifunctional outer membrane channel TolC to pump substrates to the external medium. Sequence analysis of MacB suggested that MacB has a relatively large periplasmic region. To gain insight into how MacB assembles with MacA and TolC, we determined the crystal structure of the periplasmic region of Actinobacillus actinomycetemcomitans MacB. Fold matching program reveals that parts of the MacB periplasmic region have structural motifs in common with the RND-type transporter AcrB. Since it behaved as a monomer in solution, our finding is consistent with the dimeric nature of full-length MacB, providing an insight into the assembly in the tripartite efflux pump.
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{{STRUCTURE_3ftj| PDB=3ftj | SCENE= }}
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Crystal Structure of the Periplasmic Region of MacB, a Noncanonic ABC Transporter (,).,Xu Y, Sim SH, Nam KH, Jin XL, Kim HM, Hwang KY, Lee K, Ha NC Biochemistry. 2009 May 21. PMID:19432486<ref>PMID:19432486</ref>
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===Crystal structure of the periplasmic region of MacB from Actinobacillus actinomycetemcomitans===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_19432486}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3ftj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aggregatibacter_actinomycetemcomitans Aggregatibacter actinomycetemcomitans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTJ OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:019432486</ref><references group="xtra"/>
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[[Category: Aggregatibacter actinomycetemcomitans]]
[[Category: Aggregatibacter actinomycetemcomitans]]
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[[Category: Ha, N C.]]
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[[Category: Ha, N C]]
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[[Category: Xu, Y.]]
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[[Category: Xu, Y]]
[[Category: Abc-type transporter]]
[[Category: Abc-type transporter]]
[[Category: Antibiotic resistance]]
[[Category: Antibiotic resistance]]

Revision as of 10:05, 3 December 2014

Crystal structure of the periplasmic region of MacB from Actinobacillus actinomycetemcomitans

3ftj, resolution 2.00Å

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