3g5w

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[[Image:3g5w.png|left|200px]]
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==Crystal structure of Blue Copper Oxidase from Nitrosomonas europaea==
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<StructureSection load='3g5w' size='340' side='right' caption='[[3g5w]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3g5w]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Nitrosomonas_europaea Nitrosomonas europaea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G5W FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C1O:CU-O+LINKAGE'>C1O</scene>, <scene name='pdbligand=C2O:CU-O-CU+LINKAGE'>C2O</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g5w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g5w RCSB], [http://www.ebi.ac.uk/pdbsum/3g5w PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g5/3g5w_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The two-domain multicopper oxidases are proposed to be key intermediates in the evolution of three-domain multicopper oxidases. A number of two-domain multicopper oxidases have been identified from genome sequences and are classified as type A, type B, or type C on the basis of the predicted location of the type 1 copper center. The crystal structure of blue copper oxidase, a type C two-domain multicopper oxidase from Nitrosomonas europaea, has been determined to 1.9 A resolution. Blue copper oxidase is a trimer, of which each subunit comprises two cupredoxin domains. Each subunit houses a type 1 copper site in domain 1 and a type 2/type 3 trinuclear copper cluster at the subunit-subunit interface. The coordination geometry at the trinuclear copper site is consistent with reduction of the copper ions. Although the overall architecture of blue copper oxidase is similar to nitrite reductases, detailed structural alignments show that the fold and domain orientation more closely resemble the three-domain multicopper oxidases. These observations have important implications for the evolution of nitrite reductases and multicopper oxidases.
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{{STRUCTURE_3g5w| PDB=3g5w | SCENE= }}
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Crystal structure of a two-domain multicopper oxidase: implications for the evolution of multicopper blue proteins.,Lawton TJ, Sayavedra-Soto LA, Arp DJ, Rosenzweig AC J Biol Chem. 2009 Apr 10;284(15):10174-80. Epub 2009 Feb 17. PMID:19224923<ref>PMID:19224923</ref>
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===Crystal structure of Blue Copper Oxidase from Nitrosomonas europaea===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_19224923}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3g5w]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Nitrosomonas_europaea Nitrosomonas europaea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5W OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:019224923</ref><references group="xtra"/>
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[[Category: Nitrosomonas europaea]]
[[Category: Nitrosomonas europaea]]
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[[Category: Arp, D J.]]
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[[Category: Arp, D J]]
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[[Category: Lawton, T J.]]
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[[Category: Lawton, T J]]
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[[Category: Rosenzweig, A C.]]
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[[Category: Rosenzweig, A C]]
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[[Category: Sayavedra-Soto, L A.]]
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[[Category: Sayavedra-Soto, L A]]
[[Category: Laccase]]
[[Category: Laccase]]
[[Category: Metal binding protein]]
[[Category: Metal binding protein]]

Revision as of 10:15, 3 December 2014

Crystal structure of Blue Copper Oxidase from Nitrosomonas europaea

3g5w, resolution 1.90Å

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