4g1q
From Proteopedia
(Difference between revisions)
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===Crystal structure of HIV-1 reverse transcriptase (RT) in complex with Rilpivirine (TMC278, Edurant), a non-nucleoside rt-inhibiting drug=== | ===Crystal structure of HIV-1 reverse transcriptase (RT) in complex with Rilpivirine (TMC278, Edurant), a non-nucleoside rt-inhibiting drug=== | ||
| - | {{ | + | {{ABSTRACT_PUBMED_23422558}} |
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | + | <ref group="xtra">PMID:022266819</ref><ref group="xtra">PMID:018676450</ref><ref group="xtra">PMID:017056061</ref><ref group="xtra">PMID:015115397</ref><references group="xtra"/> | |
[[Category: Human immunodeficiency virus type 1 bh10]] | [[Category: Human immunodeficiency virus type 1 bh10]] | ||
[[Category: Rhizobium loessense]] | [[Category: Rhizobium loessense]] | ||
Revision as of 12:49, 6 March 2013
Crystal structure of HIV-1 reverse transcriptase (RT) in complex with Rilpivirine (TMC278, Edurant), a non-nucleoside rt-inhibiting drug
Template:ABSTRACT PUBMED 23422558
About this Structure
4g1q is a 2 chain structure with sequence from Human immunodeficiency virus type 1 bh10 and Rhizobium loessense. Full crystallographic information is available from OCA.
Reference
- Das K, Martinez SE, Bauman JD, Arnold E. HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism. Nat Struct Mol Biol. 2012 Jan 22;19(2):253-9. doi: 10.1038/nsmb.2223. PMID:22266819 doi:10.1038/nsmb.2223
- Bauman JD, Das K, Ho WC, Baweja M, Himmel DM, Clark AD Jr, Oren DA, Boyer PL, Hughes SH, Shatkin AJ, Arnold E. Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design. Nucleic Acids Res. 2008 Sep;36(15):5083-92. Epub 2008 Aug 1. PMID:18676450 doi:10.1093/nar/gkn464
- Das K, Sarafianos SG, Clark AD Jr, Boyer PL, Hughes SH, Arnold E. Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097. J Mol Biol. 2007 Jan 5;365(1):77-89. Epub 2006 Sep 15. PMID:17056061 doi:10.1016/j.jmb.2006.08.097
- Das K, Clark AD Jr, Lewi PJ, Heeres J, De Jonge MR, Koymans LM, Vinkers HM, Daeyaert F, Ludovici DW, Kukla MJ, De Corte B, Kavash RW, Ho CY, Ye H, Lichtenstein MA, Andries K, Pauwels R, De Bethune MP, Boyer PL, Clark P, Hughes SH, Janssen PA, Arnold E. Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants. J Med Chem. 2004 May 6;47(10):2550-60. PMID:15115397 doi:http://dx.doi.org/10.1021/jm030558s
Categories: Human immunodeficiency virus type 1 bh10 | Rhizobium loessense | Bauman, J D. | D., Patel. | Das, K. | E., Arnold. | Aid | Dapy | Diarylpyrimidine | Dna polymerase | Dna recombination | Endonuclease | Hetero dimer | Hiv | Hydrolase | Hydrolase-inhibitor complex | Multifunctional enzyme | Nnrti | Nonnucleoside inhibitor | P51/p66 | R278474 | Rna-directed dna polymerase | Transferase
