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2m3m

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'''Unreleased structure'''
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{{STRUCTURE_2m3m| PDB=2m3m | SCENE= }}
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===Solution structure of a complex constisting of hDlg/SAP-97 residues 318-406 and HPV51 oncoprotein E6 residues 141-151===
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{{ABSTRACT_PUBMED_23638119}}
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The entry 2m3m is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/DLG1_HUMAN DLG1_HUMAN]] Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel.<ref>PMID:10656683</ref> <ref>PMID:12445884</ref> <ref>PMID:14699157</ref> <ref>PMID:15263016</ref> <ref>PMID:19213956</ref> <ref>PMID:20605917</ref> [[http://www.uniprot.org/uniprot/VE6_HPV51 VE6_HPV51]] Transcriptional transactivator. Binds double stranded DNA (By similarity).
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Authors: Mischo, A., Ohlenschlager, O., Gorlach, M.
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==About this Structure==
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[[2m3m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus_type_51 Human papillomavirus type 51]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M3M OCA].
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Description: Solution structure of a complex constisting of hDlg/SAP-97 residues 318-406 and HPV51 oncoprotein E6 residues 141-151
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Human papillomavirus type 51]]
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[[Category: Gorlach, M.]]
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[[Category: Mischo, A.]]
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[[Category: Ohlenschlager, O.]]
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[[Category: Dlg]]
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[[Category: E6]]
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[[Category: Hdlg]]
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[[Category: Hdlg1]]
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[[Category: Hdlgpdz2]]
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[[Category: Hpv]]
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[[Category: Oncogene protein]]
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[[Category: Oncoprotein - cell adhesion protein complex]]
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[[Category: Oncoprotein e6]]
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[[Category: Oncoprotein-cell adhesion complex]]
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[[Category: Papillomavirus e6 protein]]
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[[Category: Pdz domain]]
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[[Category: Sap-97]]
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[[Category: Viral]]

Revision as of 07:21, 16 May 2013

Template:STRUCTURE 2m3m

Contents

Solution structure of a complex constisting of hDlg/SAP-97 residues 318-406 and HPV51 oncoprotein E6 residues 141-151

Template:ABSTRACT PUBMED 23638119

Function

[DLG1_HUMAN] Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel.[1] [2] [3] [4] [5] [6] [VE6_HPV51] Transcriptional transactivator. Binds double stranded DNA (By similarity).

About this Structure

2m3m is a 2 chain structure with sequence from Homo sapiens and Human papillomavirus type 51. Full experimental information is available from OCA.

Reference

  1. ↑ Ishidate T, Matsumine A, Toyoshima K, Akiyama T. The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase. Oncogene. 2000 Jan 20;19(3):365-72. PMID:10656683 doi:10.1038/sj.onc.1203309
  2. ↑ Godreau D, Vranckx R, Maguy A, Rucker-Martin C, Goyenvalle C, Abdelshafy S, Tessier S, Couetil JP, Hatem SN. Expression, regulation and role of the MAGUK protein SAP-97 in human atrial myocardium. Cardiovasc Res. 2002 Dec;56(3):433-42. PMID:12445884
  3. ↑ Laprise P, Viel A, Rivard N. Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells. J Biol Chem. 2004 Mar 12;279(11):10157-66. Epub 2003 Dec 29. PMID:14699157 doi:10.1074/jbc.M309843200
  4. ↑ Xavier R, Rabizadeh S, Ishiguro K, Andre N, Ortiz JB, Wachtel H, Morris DG, Lopez-Ilasaca M, Shaw AC, Swat W, Seed B. Discs large (Dlg1) complexes in lymphocyte activation. J Cell Biol. 2004 Jul 19;166(2):173-8. PMID:15263016 doi:10.1083/jcb.200309044
  5. ↑ El-Haou S, Balse E, Neyroud N, Dilanian G, Gavillet B, Abriel H, Coulombe A, Jeromin A, Hatem SN. Kv4 potassium channels form a tripartite complex with the anchoring protein SAP97 and CaMKII in cardiac myocytes. Circ Res. 2009 Mar 27;104(6):758-69. doi: 10.1161/CIRCRESAHA.108.191007. Epub, 2009 Feb 12. PMID:19213956 doi:10.1161/CIRCRESAHA.108.191007
  6. ↑ Sabio G, Cerezo-Guisado MI, Del Reino P, Inesta-Vaquera FA, Rousseau S, Arthur JS, Campbell DG, Centeno F, Cuenda A. p38gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock. J Cell Sci. 2010 Aug 1;123(Pt 15):2596-604. doi: 10.1242/jcs.066514. Epub 2010, Jul 6. PMID:20605917 doi:10.1242/jcs.066514

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