4il8

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'''Unreleased structure'''
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{{STRUCTURE_4il8| PDB=4il8 | SCENE= }}
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===Crystal structure of an H329A mutant of p. aeruginosa PMM/PGM===
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{{ABSTRACT_PUBMED_23517223}}
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The entry 4il8 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/ALGC_PSEAE ALGC_PSEAE]] The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to its phosphoglucomutase activity. Essential for rhamnolipid production, an exoproduct correlated with pathogenicity, and for biofilm production.<ref>PMID:7515870</ref> <ref>PMID:10481091</ref>
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Authors: Lee, Y., Mehra-Chaudhary, R., Furdui, C., Beamer, L.
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==About this Structure==
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[[4il8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IL8 OCA].
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Description: Crystal structure of an H329A mutant of p. aeruginosa PMM/PGM
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==Reference==
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<ref group="xtra">PMID:023517223</ref><references group="xtra"/><references/>
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[[Category: Pseudomonas aeruginosa pao1]]
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[[Category: Beamer, L.]]
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[[Category: Furdui, C.]]
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[[Category: Lee, Y.]]
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[[Category: Mehra-Chaudhary, R.]]
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[[Category: A-d-phosphohexomutase]]
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[[Category: Isomerase]]
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[[Category: Phosphoserine]]

Revision as of 07:50, 14 August 2013

Template:STRUCTURE 4il8

Contents

Crystal structure of an H329A mutant of p. aeruginosa PMM/PGM

Template:ABSTRACT PUBMED 23517223

Function

[ALGC_PSEAE] The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to its phosphoglucomutase activity. Essential for rhamnolipid production, an exoproduct correlated with pathogenicity, and for biofilm production.[1] [2]

About this Structure

4il8 is a 1 chain structure with sequence from Pseudomonas aeruginosa pao1. Full crystallographic information is available from OCA.

Reference

  • Lee Y, Mehra-Chaudhary R, Furdui C, Beamer LJ. Identification of an essential active-site residue in the alpha-D-phosphohexomutase enzyme superfamily. FEBS J. 2013 Jun;280(11):2622-32. doi: 10.1111/febs.12249. Epub 2013 Apr 8. PMID:23517223 doi:10.1111/febs.12249
  1. ↑ Coyne MJ Jr, Russell KS, Coyle CL, Goldberg JB. The Pseudomonas aeruginosa algC gene encodes phosphoglucomutase, required for the synthesis of a complete lipopolysaccharide core. J Bacteriol. 1994 Jun;176(12):3500-7. PMID:7515870
  2. ↑ Olvera C, Goldberg JB, Sanchez R, Soberon-Chavez G. The Pseudomonas aeruginosa algC gene product participates in rhamnolipid biosynthesis. FEMS Microbiol Lett. 1999 Oct 1;179(1):85-90. PMID:10481091

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