2akr

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[[Image:2akr.gif|left|200px]]<br /><applet load="2akr" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2akr.gif|left|200px]]
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caption="2akr, resolution 1.90&Aring;" />
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'''Structural basis of sulfatide presentation by mouse CD1d'''<br />
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{{Structure
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|PDB= 2akr |SIZE=350|CAPTION= <scene name='initialview01'>2akr</scene>, resolution 1.90&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> and <scene name='pdbligand=CIS:(15Z)-N-((1S,2R,3E)-2-HYDROXY-1-{[(3-O-SULFO-BETA-D-GALACTOPYRANOSYL)OXY]METHYL}HEPTADEC-3-ENYL)TETRACOS-15-ENAMIDE'>CIS</scene>
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|ACTIVITY=
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|GENE= Cd1d1, Cd1.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), B2m ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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}}
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'''Structural basis of sulfatide presentation by mouse CD1d'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2AKR is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=CIS:'>CIS</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AKR OCA].
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2AKR is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AKR OCA].
==Reference==
==Reference==
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Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity., Zajonc DM, Maricic I, Wu D, Halder R, Roy K, Wong CH, Kumar V, Wilson IA, J Exp Med. 2005 Dec 5;202(11):1517-26. Epub 2005 Nov 28. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16314439 16314439]
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Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity., Zajonc DM, Maricic I, Wu D, Halder R, Roy K, Wong CH, Kumar V, Wilson IA, J Exp Med. 2005 Dec 5;202(11):1517-26. Epub 2005 Nov 28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16314439 16314439]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: cd1d]]
[[Category: cd1d]]
[[Category: mhc fold]]
[[Category: mhc fold]]
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[[Category: nkt cells]]
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[[Category: nkt cell]]
[[Category: self-antigen]]
[[Category: self-antigen]]
[[Category: sulfatide]]
[[Category: sulfatide]]
[[Category: tcr]]
[[Category: tcr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:28:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:50:50 2008''

Revision as of 13:50, 20 March 2008

Image:2akr.gif


PDB ID 2akr

Drag the structure with the mouse to rotate
, resolution 1.90Å
Ligands: and
Gene: Cd1d1, Cd1.1 (Mus musculus), B2m (Mus musculus)
Coordinates: save as pdb, mmCIF, xml



Structural basis of sulfatide presentation by mouse CD1d


Overview

Sulfatide derived from the myelin stimulates a distinct population of CD1d-restricted natural killer T (NKT) cells. Cis-tetracosenoyl sulfatide is one of the immunodominant species in myelin as identified by proliferation, cytokine secretion, and CD1d tetramer staining. The crystal structure of mouse CD1d in complex with cis-tetracosenoyl sulfatide at 1.9 A resolution reveals that the longer cis-tetracosenoyl fatty acid chain fully occupies the A' pocket of the CD1d binding groove, whereas the sphingosine chain fills up the F' pocket. A precise hydrogen bond network in the center of the binding groove orients and positions the ceramide backbone for insertion of the lipid tails in their respective pockets. The 3'-sulfated galactose headgroup is highly exposed for presentation to the T cell receptor and projects up and away from the binding pocket due to its beta linkage, compared with the more intimate binding of the alpha-glactosyl ceramide headgroup to CD1d. These structure and binding data on sulfatide presentation by CD1d have important implications for the design of therapeutics that target T cells reactive for myelin glycolipids in autoimmune diseases of the central nervous system.

About this Structure

2AKR is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity., Zajonc DM, Maricic I, Wu D, Halder R, Roy K, Wong CH, Kumar V, Wilson IA, J Exp Med. 2005 Dec 5;202(11):1517-26. Epub 2005 Nov 28. PMID:16314439

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