3gio

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[[Image:3gio.png|left|200px]]
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==Crystal structure of the TNF-alpha inducing protein (Tip alpha) from Helicobacter pylori==
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<StructureSection load='3gio' size='340' side='right' caption='[[3gio]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3gio]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GIO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GIO FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HP_0596 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 Helicobacter pylori])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gio OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gio RCSB], [http://www.ebi.ac.uk/pdbsum/3gio PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Helicobacter pylori infection is one of the highest risk factors for gastroduodenal diseases including gastric cancer. Tumor necrosis factor-alpha (TNF-alpha) is one of the essential cytokines for tumor promotion, and thus, an H. pylori protein that induces TNF-alpha is believed to play a significant role in gastric cancer development in humans. The HP0596 gene product of H. pylori strain 26695 was identified as the TNF-alpha-inducing protein (Tipalpha). Tipalpha is secreted from H. pylori as dimers and enters the gastric cells. It was shown to have a DNA-binding activity. Here, we have determined the crystal structure of Tipalpha from H. pylori. Its monomer consists of two structural domains ("mixed domain" and "helical domain"). Tipalpha exists as a dimer in the crystal, and the dimeric structure represents a novel scaffold for DNA binding. A positively charged surface patch formed across the two monomers of the Tipalpha dimer by the loop between helices alpha1 and alpha2 may be important in DNA binding.
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{{STRUCTURE_3gio| PDB=3gio | SCENE= }}
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Crystal structure of the TNF-alpha-Inducing protein (Tipalpha) from Helicobacter pylori: Insights into Its DNA-binding activity.,Jang JY, Yoon HJ, Yoon JY, Kim HS, Lee SJ, Kim KH, Kim do J, Jang S, Han BG, Lee BI, Suh SW J Mol Biol. 2009 Sep 11;392(1):191-7. Epub 2009 Jul 10. PMID:19596016<ref>PMID:19596016</ref>
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===Crystal structure of the TNF-alpha inducing protein (Tip alpha) from Helicobacter pylori===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_19596016}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3gio]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GIO OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:019596016</ref><references group="xtra"/>
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[[Category: Helicobacter pylori]]
[[Category: Helicobacter pylori]]
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[[Category: Han, B G.]]
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[[Category: Han, B G]]
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[[Category: Jang, J Y.]]
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[[Category: Jang, J Y]]
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[[Category: Jang, S.]]
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[[Category: Jang, S]]
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[[Category: Kim, D J.]]
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[[Category: Kim, D J]]
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[[Category: Kim, H S.]]
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[[Category: Kim, H S]]
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[[Category: Kim, K H.]]
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[[Category: Kim, K H]]
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[[Category: Lee, B I.]]
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[[Category: Lee, B I]]
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[[Category: Lee, S J.]]
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[[Category: Lee, S J]]
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[[Category: Suh, S W.]]
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[[Category: Suh, S W]]
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[[Category: Yoon, H J.]]
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[[Category: Yoon, H J]]
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[[Category: Yoon, J Y.]]
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[[Category: Yoon, J Y]]
[[Category: Antiparallel beta sheet]]
[[Category: Antiparallel beta sheet]]
[[Category: Dna binding protein]]
[[Category: Dna binding protein]]
[[Category: Four-helix bundle]]
[[Category: Four-helix bundle]]
[[Category: Loop]]
[[Category: Loop]]

Revision as of 09:22, 8 December 2014

Crystal structure of the TNF-alpha inducing protein (Tip alpha) from Helicobacter pylori

3gio, resolution 2.40Å

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